The effects of exercise on the lipoprotein subclass profile: A meta-analysis of 10 interventions
| Autor: | Mark A. Sarzynski, Richard L. Seip, Steven N. Blair, Claude Bouchard, Kenneth R. Wilund, Paul D. Thompson, Rian Q. Landers-Ramos, James S. Skinner, William E. Kraus, Jean-Pierre Després, James M. Hagberg, Timothy S. Church, Catherine R. Mikus, Cris A. Slentz, D. C. Rao, Tuomo Rankinen, Arthur S. Leon, Jeffrey H. Burton |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Apolipoprotein E medicine.medical_specialty Adolescent Health Status Lipoproteins Psychological intervention High-Density Lipoproteins Pre-beta Lipoproteins VLDL Article Subclass Body Mass Index Young Adult Sex Factors Regular exercise Internal medicine Humans Medicine Particle Size Exercise Life Style Nuclear Magnetic Resonance Biomolecular Aged business.industry Racial Groups Age Factors Middle Aged Lipoproteins LDL Endocrinology Meta-analysis Concomitant Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Body mass index Biomarkers Lipoprotein |
| Zdroj: | Atherosclerosis. 243:364-372 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2015.10.018 |
| Popis: | Objective The goal was to examine lipoprotein subclass responses to regular exercise as measured in 10 exercise interventions derived from six cohorts. Methods Nuclear magnetic resonance spectroscopy was used to quantify average particle size, total and subclass concentrations of very low-density lipoprotein, low-density lipoprotein, and high-density lipoprotein particles (VLDL-P, LDL-P, and HDL-P, respectively) before and after an exercise intervention in 1555 adults from six studies, encompassing 10 distinct exercise programs: APOE (N = 106), DREW (N = 385), GERS (N = 79), HERITAGE (N = 715), STRRIDE I (N = 168) and II (N = 102). Random-effects meta-analyses were performed to evaluate the overall estimate of mean change across the unadjusted and adjusted mean change values from each exercise group. Results Meta-analysis of unadjusted data showed that regular exercise induced significant decreases in the concentration of large VLDL-P, small LDL-P, and medium HDL-P and mean VLDL-P size, with significant increases in the concentration of large LDL-P and large HDL-P and mean LDL-P size. These changes remained significant in meta-analysis with adjustment for age, sex, race, baseline body mass index, and baseline trait value. Conclusions Despite differences in exercise programs and study populations, regular exercise produced putatively beneficial changes in the lipoprotein subclass profile across 10 exercise interventions. Further research is needed to examine how exercise-induced changes in lipoprotein subclasses may be associated with (concomitant changes in) cardiovascular disease risk. |
| Databáze: | OpenAIRE |
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