HSP105 expression in oral squamous cell carcinoma: correlation with clinicopathological features and outcomes
| Autor: | Johannes Alexander Lobrinus, Carla Patricia Martinelli-Kläy, Jacky Samson, Nicolas Dulguerov, Tommaso Lombardi, Souzana Arvanitidou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Heat shock protein 105 ddc:616.07 Malignancy Pathology and Forensic Medicine Metastasis 03 medical and health sciences 0302 clinical medicine Heat shock protein Internal medicine medicine Humans Oral mucosa Stage (cooking) HSP110 Heat-Shock Proteins Retrospective Studies ddc:617 business.industry Oral cancer Mouth Mucosa Cancer Retrospective cohort study 030206 dentistry medicine.disease Prognosis Immunohistochemistry stomatognathic diseases medicine.anatomical_structure Otorhinolaryngology Oral squamous cell carcinoma 030220 oncology & carcinogenesis Carcinoma Squamous Cell Periodontics Female Mouth Neoplasms Oral Surgery Neoplasm Recurrence Local business |
| Zdroj: | Journal of Oral Pathology and Medicine (2020) |
| ISSN: | 0904-2512 |
| Popis: | Background Heat shock proteins (HSPs) are released in response to stress situations, such as heat, inflammation, and infection. They are also involved in the tumor cell proliferation and prevention of apoptosis. Heat shock protein 105 (Hsp105/110) is a high-molecular-weight protein, which has been reported in many cancer types but few studies have been carried out on oral squamous cell carcinoma (OSCC). In the current study, we have focused on HSP105 expression on OSCC and evaluated their correlation with tumor clinicopathological parameters and patients' survival. Methods A retrospective study included 70 patients with OSCC of which 50 patients (71.4%) were male and 20 (28.6%) were female. The patient's information, including age, location, TNM stage, histological grade, regional metastasis, recurrence, and survival, were collected. Immunohistochemical staining for HSP105 was performed. The healthy oral mucosa (n = 10) was used as a control. The staining intensity and percentage of stained cells were semi-quantitatively evaluated, and HSP105 expression was correlated with tumor clinicopathological features and patient survival. Results Statistical analysis for HSP105 showed that there was no significant correlation with tumor clinicopathological features. However, HSP105 overexpression was associated with a decrease in the duration of patients' survival (P = .042). Conclusion This result suggests that the increased expression of the HSP105 in the OSCC could be a prognostic factor for malignancy. |
| Databáze: | OpenAIRE |
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