Sperm DNA Integrity in Men Treated for Childhood Cancer
| Autor: | Aleksander Giwercman, Eva Cavallin-Ståhl, Olof Ståhl, Patrik Romerius, Yvonne Lundberg Giwercman, Helen Gustafsson, Thomas Wiebe, K Jepson, Thomas Relander, Marcello Spanò, Kerstin Löfvander Thapper, Christian Moëll |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent Offspring media_common.quotation_subject Antineoplastic Agents Fertility DNA Fragmentation Biology Gastroenterology Male infertility Young Adult Neoplasms Statistical significance Internal medicine medicine Humans Survivors Child Infertility Male media_common Gynecology Radiotherapy Infant Newborn Infant Cancer DNA Odds ratio Middle Aged medicine.disease Spermatozoa Sperm Confidence interval Oncology Child Preschool |
| Zdroj: | Clinical Cancer Research. 16:3843-3850 |
| ISSN: | 1557-3265 1078-0432 |
| DOI: | 10.1158/1078-0432.ccr-10-0140 |
| Popis: | Purpose: It is not known whether childhood cancer and its treatment are associated with sperm DNA damage, which subsequently affects fertility and might be transmitted to the offspring. The aim of this study is to assess DNA fragmentation index (DFI) as an indicator of sperm DNA integrity in childhood cancer survivors (CCS), with treatment regimen taken into account. Experimental Design: In 99 CCS and 193 age-matched healthy controls, DFI was assessed by using sperm chromatin structure assay. Results: In the whole group of CCS, DFI was increased compared with the controls, with borderline statistical significance [mean difference, 1.8%; 95% confidence interval (95% CI), −0.0088%-3.7%]. Those treated with radiotherapy only (mean difference, 6.0%; 95% CI, 1.6–10%) or surgery only (mean difference, 2.9%; 95% CI, 0.083–5.8%) had statistically significantly higher DFI than the controls. The odds ratio (OR) for having DFI >20%, which is associated with reduced fertility, was significantly increased in CCS compared with the control group (OR, 2.2; 95% CI, 1.1–4.4). For the radiotherapy-only group, the OR was even higher (OR, 4.9; 95% CI, 1.3–18). DFI was not associated with dose of scattered testicular irradiation or type of chemotherapy given. Conclusions: DFI was increased in CCS, with those treated with chemotherapy being the only exception. This sperm DNA impairment may be associated with the disease per se rather than due to the treatment, and may have negative consequences in terms of fertility and risk of transmission to the offspring. Clin Cancer Res; 16(15); 3843–50. ©2010 AACR. |
| Databáze: | OpenAIRE |
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