Proinflammatory cytokines predict the incidence and progression of distal sensorimotor polyneuropathy: KORA F4/FF4 Study
| Autor: | Dan Ziegler, Wolfgang Koenig, Julia M. Kannenberg, Barbara Thorand, Wolfgang Rathmann, Christian Herder, Christa Meisinger, Maren Carstensen-Kirberg, Cornelia Huth, Sonja Püttgen, Margit Heier, Michael Roden, Annette Peters |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Oncology medicine.medical_specialty Diabetic neuropathy Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Proinflammatory cytokine Polyneuropathies 03 medical and health sciences 0302 clinical medicine Diabetic Neuropathies Risk Factors Internal medicine Diabetes mellitus Diabetes Mellitus Prevalence Internal Medicine medicine Humans Prospective Studies education Prospective cohort study Aged Subclinical infection Aged 80 and over Inflammation Advanced and Specialized Nursing education.field_of_study business.industry Incidence Odds ratio Middle Aged Intercellular Adhesion Molecule-1 medicine.disease C-Reactive Protein Immunology Cohort Disease Progression Cytokines Female business Biomarkers Follow-Up Studies |
| Zdroj: | Diabetes Care 40, 569-576 (2017) |
| Popis: | OBJECTIVE Experimental and epidemiological studies have implicated inflammatory processes in the pathogenesis of distal sensorimotor polyneuropathy (DSPN), but prospective studies are lacking. We hypothesized that biomarkers of inflammation predict the development and progression of DSPN in a population-based cohort. RESEARCH DESIGN AND METHODS This study was based on participants aged 62–81 years from the Cooperative Health Research in the Region of Augsburg (KORA) F4/FF4 cohort, with a mean follow-up of 6.5 years. The predictive value of systemic levels of eight biomarkers of inflammation was assessed for incident DSPN in 133 incident case subjects and 397 individuals without incident DSPN, and for DSPN progression in 57 patients with prevalent DSPN at both time points. RESULTS Higher hs-CRP, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1 receptor antagonist (IL-1RA), and soluble intercellular adhesion molecule (sICAM-1) and lower adiponectin levels were associated with incident DSPN in age- and sex-adjusted analysis; IL-18 and omentin were not. IL-6 (odds ratio 1.31 [95% CI 1.00–1.71]) and TNF-α (odds ratio 1.31 [95% CI 1.03–1.67]) remained associated with incident DSPN after adjusting for known DSPN risk factors. The addition of both cytokines to a clinical risk model improved model fit and reclassification. sICAM-1 and IL-1RA were positively associated with progression of DSPN. CONCLUSIONS Systemic subclinical and vascular inflammation predicted both the onset and progression of DSPN over 6.5 years in an older general population. Thus modulation of inflammatory processes may be relevant to prevent and/or treat diabetic neuropathy. |
| Databáze: | OpenAIRE |
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