Multiparametric Magnetic Resonance Imaging-Ultrasound Fusion Transperineal Prostate Biopsy: Diagnostic Accuracy from a Single Center Retrospective Study
| Autor: | Stefano Alba, Antonio Greco, Camillo Palmieri, Vincenzo Andracchio, Vincenzo Pagliarulo, Manlio Cappa, Marcello Scarcia, Giuseppe Mario Ludovico, Francesco Chiaradia, Luigi Ascalone, Andrea Fulco |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Prostate biopsy medicine.diagnostic_test image-guided business.industry Communication Ultrasound Neoplasms. Tumors. Oncology. Including cancer and carcinogens Retrospective cohort study Magnetic resonance imaging ultrasonography medicine.disease Single Center prostatic neoplasms Prostate cancer Oncology Biopsy medicine magnetic resonance imaging biopsy Radiology business Multiparametric Magnetic Resonance Imaging RC254-282 |
| Zdroj: | Cancers, Vol 13, Iss 4833, p 4833 (2021) Cancers |
| ISSN: | 2072-6694 |
| Popis: | Simple Summary The introduction of imaging techniques has improved the diagnostic pathway for prostate cancer. In this study we compared the diagnostic accuracy of multiparametric MRI with fusion ultrasound-guided prostate biopsy and standard biopsy, both performed through the transperineal route. Our results support the combined targeted and standard biopsy pathway to reduce the risk of missing clinically significant prostate cancer. Abstract The management of prostate biopsy in men with clinical suspicion of prostate cancer has changed in the last few years, especially with the introduction of imaging techniques, to overcome the low efficacy of risk stratification based on PSA levels. Here, we aimed to compare the diagnostic accuracy of multiparametric MRI with fusion ultrasound-guided prostate biopsy and standard biopsy, both performed through the transperineal route. To this end, we retrospectively analyzed 272 patients who underwent combined transperineal targeted and standard biopsy during the same session. The primary outcome was to compare the cancer detection rate between targeted and standard biopsy. The secondary outcome was to evaluate the added value of combined targeted and standard biopsy approach as compared to only targeted or standard biopsy. Results showed that a rate of 16.7% clinically significant tumors (International Society of Urological Pathology (ISUP) grade ≥ 2) would have been lost if only the standard biopsy had been used. The combined targeted and standard biopsy showed an added value of 10.3% and 9.9% in reducing the risk of prostate cancer missing after targeted or standard biopsy alone, respectively. The combined targeted and standard biopsy pathway is recommended to reduce the risk of missing clinically significant prostate cancer. |
| Databáze: | OpenAIRE |
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