Diagnostic and prognostic value of circular RNAs in hepatocellular carcinoma
| Autor: | Jin‐Yu Sun, Xiao‐Xin Mu, Xiao-Yu Zhang, Yi‐Zhi Cao, Jian Gu, Xiao Zhou |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Carcinoma Hepatocellular diagnostic biomarker Reviews Review medicine.disease_cause Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Overall survival Biomarkers Tumor Humans Prognostic biomarker Stage (cooking) prognostic biomarker business.industry Advanced stage Liver Neoplasms Cell Biology RNA Circular hepatocellular carcinoma medicine.disease Prognosis digestive system diseases 030104 developmental biology 030220 oncology & carcinogenesis Hepatocellular carcinoma Molecular Medicine Disease Susceptibility Carcinogenesis business Closed loop Cell-Free Nucleic Acids circular RNAs |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 |
| Popis: | Hepatocellular carcinoma (HCC) is the sixth most common malignant tumour, which has posed a heavy health and financial burden worldwide. Due to limited symptoms at the early stage and the limitation in current biomarkers, HCC patients are usually diagnosed at the advanced stage with a pessimistic overall survival rate. Circular RNAs (circRNAs) are a subclass of single‐stranded RNAs characterized by a covalently closed loop structure without 3’‐ or 5’‐end. With advances in high‐throughput sequencing technology and bioinformatics, accumulating studies have demonstrated the promotor or suppressor roles of circRNAs in the carcinogenesis, progression, and metastasis of HCC. Moreover, circRNAs are characteristic of higher abundance, stability and conservation compared with linear RNAs. Therefore, circRNAs have emerged as one of the most promising diagnostic and prognostic biomarkers for HCC with reliable accuracy, sensitivity and specificity. In this review, we briefly introduce the characteristics of circRNAs and summarize the roles of circRNAs in the biological procedures of HCC. Furthermore, we provide an overview on the potential diagnostic and prognostic value of circRNAs as biomarkers for patients with HCC. Finally, we discuss future perspectives of circRNAs in cancer research. |
| Databáze: | OpenAIRE |
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