Extraction of lipid membrane incorporated vitamin E by sucrose polyesters
| Autor: | Gerald W. Buchanan, Gerald G. McManus, Harold C. Jarrell |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Magnetic Resonance Spectroscopy
Sucrose 1 2-Dipalmitoylphosphatidylcholine Surface Properties Lipid Bilayers Molecular Conformation Palmitates Phospholipid Models Biological Biochemistry chemistry.chemical_compound Mole Vitamin E Tocopherol Lipid bilayer Molecular Biology Chromatography Organic Chemistry food and beverages Cell Biology Deuterium Polyester Membrane Solid-state nuclear magnetic resonance chemistry Liposomes lipids (amino acids peptides and proteins) |
| Zdroj: | Chemistry and Physics of Lipids. 112:47-58 |
| ISSN: | 0009-3084 |
| DOI: | 10.1016/s0009-3084(01)00162-1 |
| Popis: | 2H and 31P solid state NMR have been used to probe, at the molecular level, the interaction between structurally different sucrose polyesters and a phospholipid membrane into which alpha-tocopherol and specifically deuterated alpha-[5,7-(2)H(6)] tocopherol has been incorporated. Our results show that at high concentration (or=10 mol%) sucrose octapalmitate (SOP) and sucrose hexapalmitate (SHxP) deplete bilayer-associated alpha-tocopherol in dipalmitoyl phosphatidalcholine (DPPC) multilamellar dispersions and preferentially sequester the alpha-tocopherol into a fluid sucrose polyesters (SPE) phase located proximal to the membrane surface. It is demonstrated that the ability of SPEs to function as a 'lipophilic sink' depends strongly on sucrose polyester concentration and degree of esterification. |
| Databáze: | OpenAIRE |
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