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Tuberculosis (TB) screening of healthcare workers (HCWs) is an important component of hospital infection control programs. Many institutions have replaced tuberculin skin tests (TSTs) with interferon-release gamma assays (IGRAs). Challenges of IGRA tests include daily fluctuations of IGRA values, serial testing variability, higher conversion rates of IGRAs than TSTs, and indeterminate IGRA results. In addition, reversions of positive QuantiFERON® TB test (QFT) with low cut-off values (0.35 IU/mL to 1 IU/mL) to negative have also raised concerns. Additional data is needed for IGRA use in HCWs. An Employee Health algorithm was created prior to implementation of QFT testing at our institution (Figure 1). Background 1The Ohio State University College of Medicine, Columbus, Ohio. |
