The effects of pulsatile cardiopulmonary bypass on acute kidney injury
| Autor: | Koray Ak, Taylan Adademir, Mehmet Emre Elçi, Maher Aljodi, Selim Isbir, Sinan Arsan |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Acute Renal Injury Turkey Biomedical Engineering Pulsatile flow Medicine (miscellaneous) Bioengineering Enzyme-Linked Immunosorbent Assay Kidney Function Tests law.invention Biomaterials Lipocalin-2 law Internal medicine Proto-Oncogene Proteins medicine Cardiopulmonary bypass Humans Prospective Studies Aorta Aged Cardiopulmonary Bypass business.industry Acute kidney injury Interleukin-18 General Medicine Acute Kidney Injury Middle Aged medicine.disease Constriction Lipocalins Cardiac surgery Surgery Neutrophil gelatinase-associated lipocalin Treatment Outcome Pulsatile Flow Cardiology Interleukin 18 Female business Biomarkers Acute-Phase Proteins |
| Zdroj: | The International journal of artificial organs. 35(7) |
| ISSN: | 1724-6040 |
| Popis: | Purpose: Protective effect of pulsatile flow cardiopulmonary bypass (CPB) on the occurrence of acute renal injury is still a matter of debate. The objective of this study was to compare the effects of pulsatile and non-pulsatile cardiopulmonary bypass on kidneys using Urinary neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) as the markers of renal injury. Methods: 85 consecutive patients with normal preoperative renal function were prospectively enrolled in the study. Pulsatile perfusion (Group P) and non-pulsatile perfusion (Group NP) was used in 42 and 43 of the patients, respectively, during aortic cross-clamping period. NGAL and IL-18 were analyzed using ELISA in urine samples obtained preoperatively, and at 2, 12, and 24 h after CPB. Results: There was no significant difference between the groups in terms of perioperative renal function tests. IL-18 levels measured at 12 h after CPB were significantly lower in Group P, compared to Group NP (pConclusions: Low IL-18 and NGAL levels found in the pulsatile perfusion group might suggest the use of pulsatile flow resulted in better kidney protection. |
| Databáze: | OpenAIRE |
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