Catechol O-methyltransferase and monoamine oxidase A genotypes, and plasma catecholamine metabolites in bipolar and schizophrenic patients
| Autor: | Sonia Bustamante, Leire Erkoreka, Mercedes Zumárraga, Nieves Basterreche, María I. Zamalloa, Lucía Inchausti, Ricardo Dávila, José Guimón, Aurora Arrúe, Miguel Angel Gonzalez-Torres, Biotza Goienetxea |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Bipolar Disorder 3 4-Dihydroxyphenylacetic acid Genotype Minisatellite Repeats Pharmacology Catechol O-Methyltransferase Methoxyhydroxyphenylglycol Cellular and Molecular Neuroscience chemistry.chemical_compound Catecholamines Dopamine medicine Humans Promoter Regions Genetic Monoamine Oxidase Aged Analysis of Variance Polymorphism Genetic Catechol-O-methyl transferase biology Homovanillic acid Homovanillic Acid Cell Biology Middle Aged Monoamine neurotransmitter chemistry Schizophrenia Catecholamine biology.protein 3 4-Dihydroxyphenylacetic Acid Female 3-Methoxy-4-hydroxyphenylglycol Monoamine oxidase A medicine.drug |
| Zdroj: | Neurochemistry International. 56:774-779 |
| ISSN: | 0197-0186 |
| DOI: | 10.1016/j.neuint.2010.02.015 |
| Popis: | Metabolites of dopamine and norepinephrine measured in the plasma have long been associated with symptomatic severity and response to treatment in schizophrenic, bipolar and other psychiatric patients. Plasma concentrations of catecholamine metabolites are genetically regulated. The genes encoding enzymes that are involved in the synthesis and degradation of these monoamines are candidate targets for this genetic regulation. We have studied the relationship between the Val158Met polymorphism in catechol O-methyltransferase gene, variable tandem repeat polymorphisms in the monoamine oxidase A gene promoter, and plasma concentrations of 3-methoxy-4-hydroxyphenylglycol, 3,4-dihydroxyphenylacetic acid and homovanillic acid in healthy control subjects as well as in untreated schizophrenic and bipolar patients. We found that the Val158Met substitution in catechol O-methyltransferase gene influences the plasma concentrations of homovanillic and 3,4-dihydroxyphenylacetic acids. Although higher concentrations of plasma homovanillic acid were found in the high-activity ValVal genotype, this mutation did not affect the plasma concentration of 3-methoxy-4-hydroxyphenylglycol. 3,4-dihydroxyphenylacetic acid concentrations were higher in the low-activity MetMet genotype. Interestingly, plasma values 3-methoxy-4-hydroxyphenylglycol were greater in schizophrenic patients and in bipolar patients than in healthy controls. Our results are compatible with the previously reported effect of the Val158Met polymorphism on catechol O-methyltransferase enzymatic activity. Thus, our results suggest that this polymorphism, alone or associated with other polymorphisms, could have an important role in the genetic control of monoamine concentration and its metabolites. |
| Databáze: | OpenAIRE |
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