A comparative evaluation of safety and efficacy of rosuvastatin, simvastatin, and atorvastatin in patients of type 2 diabetes mellitus with dyslipidemia
| Autor: | P N Khandelwal, Mirza Shiraz Baig, Samir Maruti Adsule, Prakashchandra Rambhau Gade |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Atorvastatin Aatorvastatin Gastroenterology Internal medicine Diabetes mellitus Internal Medicine medicine simvastatin Rosuvastatin business.industry dyslipidemia nutritional and metabolic diseases Type 2 Diabetes Mellitus type-2 diabetes mellitus medicine.disease Metformin Glimepiride Endocrinology Simvastatin Original Article lipids (amino acids peptides and proteins) business rosuvastatin Dyslipidemia medicine.drug |
| Zdroj: | International Journal of Diabetes in Developing Countries |
| ISSN: | 0973-3930 |
| DOI: | 10.4103/0973-3930.53124 |
| Popis: | AIM: To evaluate and compare the safety and efficacy of rosuvastatin, simvastatin, and atorvastatin in patients of type 2 diabetes mellitus with dyslipidemia. MATERIALS AND METHODS: This open-label, randomized, parallel group, comparative, prospective study of 12-weeks duration included 60 patients of type-2 diabetes with dyslipidemia having good glycemic control with fixed dose combination of tablet glimepiride + metformin and divided into three groups of twenty each. Group-1 patients have received tablet rosuvastatin 10 mg once daily, group-2 received tablet atorvastatin 10 mg once daily, and group-3 received tablet simvastatin 10 mg once daily for 12 weeks each. The levels of serum cholesterol, serum triglyceride, LDL, VLDL, and HDL were assessed at baseline and at the end of 12 weeks. RESULTS: The mean serum cholesterol, serum triglyceride, LDLc, and VLDLc levels were significantly reduced on therapy (P 0.05). Conclusion: 10 mg of rosuvastatin was comparable to 10 mg of atorvastatin and more efficacious than 10 mg simvastatin in reducing LDL levels after 12 weeks of therapy in patients of type 2 diabetes mellitus with dyslipidemia. |
| Databáze: | OpenAIRE |
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