Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation

Autor:	Morgan S. Schrock, Louise Y.Y. Fong, Donald Quimby, Kay Huebner, Teresa Druck, Xueliang Pan, James Liu, Jin Sun, Rulong Shen, Nicola Zanesi
Rok vydání:	2016
Předmět:	0301 basic medicine Male Cancer Research medicine.medical_specialty Skin Neoplasms DNA damage Cell Inflammation Biology tumor suppressor‐deficient mice Benzanthracene 03 medical and health sciences Mice 0302 clinical medicine DMBA‐induced skin tumors FHIT Internal medicine medicine Animals Radiology Nuclear Medicine and imaging neoplasms Carcinogen Skin Original Research Cancer Biology tumor prevention Mice Knockout zinc supplementation medicine.disease 3. Good health Acid Anhydride Hydrolases Neoplasm Proteins Tumor Burden Disease Models Animal Zinc 030104 developmental biology Endocrinology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Knockout mouse Dietary Supplements Carcinoma Squamous Cell Female medicine.symptom Skin cancer Fhit knockout mice DNA Damage
Zdroj:	Cancer Medicine
ISSN:	2045-7634
Popis:	Inadequate dietary Zn consumption increases susceptibility to esophageal and other cancers in humans and model organisms. Since Zn supplementation can prevent cancers in rodent squamous cell carcinoma (SCC) models, we were interested in determining if it could have a preventive effect in a rodent skin cancer model, as a preclinical basis for considering a role for Zn in prevention of human nonmelanoma skin cancers, the most frequent cancers in humans. We used the 7,12‐dimethyl benzanthracene carcinogen/phorbol myristate acetate tumor promoter treatment method to induce skin tumors in Zn‐sufficient wild‐type and Fhit (human or mouse protein) knockout mice. Fhit protein expression is lost in >50% of human cancers, including skin SCCs, and Fhit‐deficient mice show increased sensitivity to carcinogen induction of tumors. We hypothesized that: (1) the skin cancer burdens would be reduced by Zn supplementation; (2) Fhit −/−(Fhit, murine fragile histidine triad gene) mice would show increased susceptibility to skin tumor induction versus wild‐type mice. 30 weeks after initiating treatment, the tumor burden was increased ~2‐fold in Fhit −/− versus wild‐type mice (16.2 versus 7.6 tumors, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74d7b258d03c0e9070cc52ddb377e80 https://pubmed.ncbi.nlm.nih.gov/27185213 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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