Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis
| Autor: | Maciej Szmitkowski, Edyta Katarzyna Głażewska, Monika Zajkowska, Sławomir Ławicki, Grażyna Ewa Będkowska, Przemysław Chorąży |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Vascular Endothelial Growth Factor A 0301 basic medicine Macrophage colony-stimulating factor Pathology medicine.medical_specialty Article Subject Angiogenesis medicine.medical_treatment Immunology Breast Neoplasms Enzyme-Linked Immunosorbent Assay Malignancy Sensitivity and Specificity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer lcsh:Pathology Humans Medicine Aged business.industry Macrophage Colony-Stimulating Factor Cancer Cell Biology Middle Aged medicine.disease Vascular endothelial growth factor Vascular endothelial growth factor A 030104 developmental biology Cytokine ROC Curve chemistry 030220 oncology & carcinogenesis Cancer research Female Transcriptional Elongation Factors business lcsh:RB1-214 Research Article |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 2016 (2016) |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | Breast cancer (BC) is the most common malignancy in women. Vascular endothelial growth factor (VEGF) has been described as an important regulator of angiogenesis which plays a vital role in the progression of tumor. Macrophage colony-stimulating factor (M-CSF) is a cytokine whose functions include regulation of hematopoietic lineages cells growth, proliferation, and differentiation. We investigated the diagnostic significance of these parameters in comparison to CA15-3 in BC patients and in relation to the control group (benign breast tumor and healthy women). Plasma levels of the tested parameters were determined by ELISA and CA15-3 was determined by CMIA. VEGF was shown to be comparable to CA15-3 values of sensitivity in BC group and, what is more important, higher values in early stages of BC. VEGF was also the only parameter which has statistically significant AUC in all stages of cancer. M-CSF has been shown to be comparable to CA15-3 and VEGF, specificity, and AUC values only in stages III and IV of BC. These results indicate the usefulness and high diagnostic power of VEGF in the detection of BC. Also, it occurred to be the best candidate for cancer diagnostics in stages I and II of BC and in the differentiation between BC and benign cases. |
| Databáze: | OpenAIRE |
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