Progenitor 'Mycobacterium canettii' clone responsible for lymph node tuberculosis epidemic, Djibouti

Autor: Celine Dehan, Christian Boulais, Yolande Hauck, Charles Soler, Mohamed Osman Hassan, Émilie Martin, Christine Pourcel, Gilles Vergnaud, Christophe Martinaud, Dina Andriamanantena, Yann Blouin, Geraldine Cazajous, Rithy Vong
Přispěvatelé: Institut de génétique et microbiologie [Orsay] (IGM), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), SERRE, Marie-Claude
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Epidemiology
Prevalence
Clone (cell biology)
lcsh:Medicine
Human pathogen
Tuberculosis
Lymph Node
Cluster Analysis
Clustered Regularly Interspaced Short Palindromic Repeats
Lymph Node Tuberculosis
Child
Phylogeny
0303 health sciences
biology
Mycobacterium canettii
Middle Aged
3. Good health
Vitamin B 12
Infectious Diseases
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
tuberculosis
Child
Preschool
Djibouti
Female
Microbiology (medical)
Adult
Tuberculosis
Adolescent
Polymorphism
Single Nucleotide
lcsh:Infectious and parasitic diseases
Mycobacterium
Mycobacterium tuberculosis
03 medical and health sciences
Young Adult
parasitic diseases
[SDV.BBM] Life Sciences [q-bio]/Biochemistry
Molecular Biology
medicine
Humans
lcsh:RC109-216
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology
lymph node tuberculosis
030304 developmental biology
030306 microbiology
Research
lcsh:R
Outbreak
Infant
biology.organism_classification
medicine.disease
Virology
tuberculosis and other mycobacteria
Biosynthetic Pathways
nervous system
disease outbreaks
Genome
Bacterial
Zdroj: Emerging Infectious Diseases
Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2014, 20 (1), pp.21-8
Emerging Infectious Diseases, Vol 20, Iss 1, Pp 21-28 (2014)
ISSN: 1080-6040
1080-6059
Popis: Two outbreaks among expatriate children were caused by an epidemic clone from the Horn of Africa.
“Mycobacterium canettii,” an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberculosis in children, belong to a unique epidemic clone within M. canettii. Evolution of this clone, which has been recovered regularly since 1983, may mimic the birth of M. tuberculosis. Thus, recognizing this organism and identifying its reservoir are clinically important.
Databáze: OpenAIRE
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