Progenitor 'Mycobacterium canettii' clone responsible for lymph node tuberculosis epidemic, Djibouti
Autor: | Celine Dehan, Christian Boulais, Yolande Hauck, Charles Soler, Mohamed Osman Hassan, Émilie Martin, Christine Pourcel, Gilles Vergnaud, Christophe Martinaud, Dina Andriamanantena, Yann Blouin, Geraldine Cazajous, Rithy Vong |
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Přispěvatelé: | Institut de génétique et microbiologie [Orsay] (IGM), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), SERRE, Marie-Claude |
Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
Male
Epidemiology Prevalence Clone (cell biology) lcsh:Medicine Human pathogen Tuberculosis Lymph Node Cluster Analysis Clustered Regularly Interspaced Short Palindromic Repeats Lymph Node Tuberculosis Child Phylogeny 0303 health sciences biology Mycobacterium canettii Middle Aged 3. Good health Vitamin B 12 Infectious Diseases [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology tuberculosis Child Preschool Djibouti Female Microbiology (medical) Adult Tuberculosis Adolescent Polymorphism Single Nucleotide lcsh:Infectious and parasitic diseases Mycobacterium Mycobacterium tuberculosis 03 medical and health sciences Young Adult parasitic diseases [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology medicine Humans lcsh:RC109-216 [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology lymph node tuberculosis 030304 developmental biology 030306 microbiology Research lcsh:R Outbreak Infant biology.organism_classification medicine.disease Virology tuberculosis and other mycobacteria Biosynthetic Pathways nervous system disease outbreaks Genome Bacterial |
Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2014, 20 (1), pp.21-8 Emerging Infectious Diseases, Vol 20, Iss 1, Pp 21-28 (2014) |
ISSN: | 1080-6040 1080-6059 |
Popis: | Two outbreaks among expatriate children were caused by an epidemic clone from the Horn of Africa. “Mycobacterium canettii,” an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberculosis in children, belong to a unique epidemic clone within M. canettii. Evolution of this clone, which has been recovered regularly since 1983, may mimic the birth of M. tuberculosis. Thus, recognizing this organism and identifying its reservoir are clinically important. |
Databáze: | OpenAIRE |
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