ALK in Non-Small Cell Lung Cancer (NSCLC) Pathobiology, Epidemiology, Detection from Tumor Tissue and Algorithm Diagnosis in a Daily Practice
| Autor: | Paul Hofman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.drug_class Cell ALK rearrangement non-small cell lung cancer (NSCLC) Review Biology lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine FISH hemic and lymphatic diseases Carcinoma medicine molecular biology Lung cancer Lung biology medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ALK inhibitor lung cancer 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis immunohistochemistry Immunohistochemistry ALK rearrangement lung cancer biology immunohistochemistry FISH molecular biology Algorithm Tyrosine kinase |
| Zdroj: | Cancers, Vol 9, Iss 8, p 107 (2017) Cancers |
| ISSN: | 2072-6694 |
| Popis: | Patients with advanced-stage non-small cell lung carcinoma (NSCLC) harboring an ALK rearrangement, detected from a tissue sample, can benefit from targeted ALK inhibitor treatment. Several increasingly effective ALK inhibitors are now available for treatment of patients. However, despite an initial favorable response to treatment, in most cases relapse or progression occurs due to resistance mechanisms mainly caused by mutations in the tyrosine kinase domain of ALK. The detection of an ALK rearrangement is pivotal and can be done using different methods, which have variable sensitivity and specificity depending, in particular, on the quality and quantity of the patient's sample. This review will first highlight briefly some information regarding the pathobiology of an ALK rearrangement and the epidemiology of patients harboring this genomic alteration. The different methods used to detect an ALK rearrangement as well as their advantages and disadvantages will then be examined and algorithms proposed for detection in daily routine practice. |
| Databáze: | OpenAIRE |
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