Water in Ras Superfamily Evolution
| Autor: | Carla Mattos, Kendra Marcus |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Models
Molecular 010304 chemical physics Phylogenetic tree Cell growth Water General Chemistry GTPase Computational biology Biology Protein superfamily 010402 general chemistry Cell morphology 01 natural sciences 0104 chemical sciences Proto-Oncogene Proteins p21(ras) Vesicular transport protein Computational Mathematics 0103 physical sciences Rab Ras superfamily |
| Zdroj: | Journal of Computational Chemistry. 41:402-414 |
| ISSN: | 1096-987X 0192-8651 |
| DOI: | 10.1002/jcc.26060 |
| Popis: | The Ras GTPase superfamily of proteins coordinates a diverse set of cellular outcomes, including cell morphology, vesicle transport, and cell proliferation. Primary amino acid sequence analysis has identified Specificity determinant positions (SDPs) that drive diversified functions specific to the Ras, Rho, Rab, and Arf subfamilies (Rojas et al. 2012, J Cell Biol 196:189-201). The inclusion of water molecules in structural and functional adaptation is likely to be a major response to the selection pressures that drive evolution, yet hydration patterns are not included in phylogenetic analysis. This article shows that conserved crystallographic water molecules coevolved with SDP residues in the differentiation of proteins within the Ras superfamily of small GTPases. The patterns of water conservation between protein subfamilies parallel those of sequence-based evolutionary trees. Thus, hydration patterns have the potential to help elucidate functional significance in the evolution of amino acid residues observed in phylogenetic analysis of homologous proteins. © 2019 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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