Age-related DNA methylation changes are sex-specific: a comprehensive assessment
| Autor: | Paolo Garagnani, Maria Giulia Bacalini, Amedeo Gagliardi, I. I. Yusipov, Noémie Gensous, Silvia Polidoro, Chiara Pirazzini, Maria Vedunova, Maddalena Milazzo, Alena I. Kalyakulina, Claudio Franceschi, Mikhail Krivonosov, Mikhail Ivanchenko, Francesco Ravaioli, Cristina Giuliani, Giovanni Fiorito |
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| Přispěvatelé: | Yusipov, Igor, Bacalini, Maria Giulia, Kalyakulina, Alena, Krivonosov, Mikhail, Pirazzini, Chiara, Gensous, Noémie, Ravaioli, Francesco, Milazzo, Maddalena, Giuliani, Cristina, Vedunova, Maria, Fiorito, Giovanni, Gagliardi, Amedeo, Polidoro, Silvia, Garagnani, Paolo, Ivanchenko, Mikhail, Franceschi, Claudio |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Aging meta-analysi Epigenesis Genetic 0302 clinical medicine Databases Genetic Myocardial infarction media_common Genetics Aged 80 and over 0303 health sciences Longevity Age Factors Atrial fibrillation Methylation Middle Aged Sex specific Hypertensive heart disease Meta-analysis DNA methylation Cardiology Female Proline-Rich Protein Domains medicine.symptom Microtubule-Associated Proteins Research Paper Adult Down syndrome medicine.medical_specialty Adolescent media_common.quotation_subject Concentric hypertrophy Biology Asymptomatic 03 medical and health sciences Young Adult Sex Factors Internal medicine medicine sex Humans Epigenetics Gene 030304 developmental biology Aged business.industry Proportional hazards model variability whole blood Cell Biology DNA Methylation medicine.disease meta-analysis Heart failure ATPases Associated with Diverse Cellular Activities CpG Islands methylation Down Syndrome business 030217 neurology & neurosurgery Mace |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | In humans, females live longer than males but experience a worse longevity, as genome-wide autosomal DNA methylation differences between males and females have been reported. So far, few studies have investigated if DNA methylation is differently affected by aging in males and females. We performed a meta-analysis of 4 large whole blood datasets, comparing 4 aspects of epigenetic age-dependent remodeling between the two sexes: differential methylation, variability, epimutations and entropy. We reported that a large fraction (43%) of sex-associated probes undergoes age-associated DNA methylation changes, and that a limited number of probes shows age-by-sex interaction. We experimentally validated 2 regions mapping inFIGNandPRR4genes, and showed sex-specific deviations of their methylation patterns in models of decelerated (centenarians) and accelerated (Down syndrome) aging. While we did not find sex differences in the age-associated increase in epimutations and in entropy, we showed that the number of probes showing age-related increase in methylation variability is 15 times higher in males compared to females. Our results can offer new epigenetic tools to study the interaction between aging and sex and can pave the way to the identification of molecular triggers of sex differences in longevity and age-related diseases prevalence. |
| Databáze: | OpenAIRE |
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