COVID-19 pneumonia treated with ultra-low doses of radiotherapy (ULTRA-COVID study): a single institution report of two cases
| Autor: | Vladimir Suárez-Gironzini, Teresa Filigheddu, Daniel Rivas, Escarlata López, Jose Gonzalez, Manuel Pérez, Alba Sanjuan-Sanjuan, Luis Larrea, Luis Gorospe, Elena Moreno-Olmedo, Cristina Mínguez |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) medicine.medical_treatment Cytokine storm 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine COVID-19 pneumonitis medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Intensive care medicine Aged Mechanical ventilation Aged 80 and over Radiation Radiotherapy business.industry SARS-CoV-2 COVID-19 Radiotherapy Dosage Pneumonia treated Inflamatory response medicine.disease Radiation therapy Clinical trial Pneumonia Treatment Outcome Oncology Radiology Nuclear Medicine and imaging 030220 oncology & carcinogenesis Radiological weapon Original Article Female business Preliminary Data |
| Zdroj: | Strahlentherapie und Onkologie Strahlentherapie Und Onkologie |
| DOI: | 10.1007/s00066-020-01743-4.pdf |
| Popis: | Introduction Since the outbreak of coronavirus disease 2019 (COVID-19) pandemic, healthcare systems have focused their efforts into finding a treatment to avoid the fatal outcomes of severe acute respiratory syndrome due to coronavirus‑2 (SARS-CoV-2). Benefits and risks of systemic treatments remain unclear, with multiple clinical trials still ongoing. Radiotherapy could play a role in reducing the inflammatory response in the lungs and relieve life-threatening symptoms. Methods We designed a prospective study of Ultra-Low Doses of Therapy with Radiation Applied to COVID-19 (ULTRA-COVID) for patients who suffer pneumonia, are not candidates for invasive mechanical ventilation and show no improvement with medical therapy. Results We present the preliminary results of two patients diagnosed with COVID-19 pneumonia treated with ULTRA-COVID. After one radiotherapy session, significant clinical response and a good radiological response was observed in both cases, resulting in both patients being discharged from hospital in less than 2 weeks after radiation treatment. Conclusion Preliminary clinical and radiological results suggest a potential benefit of treating COVID-19 pneumonia with ULTRA-COVID. ClinicalTrials.gov Identifier: NCT04394182 |
| Databáze: | OpenAIRE |
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