Endometrial cancer
| Autor: | Beatrice Susil, Tom Jobling, Martin K. Oehler, Andrew Ryan |
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| Rok vydání: | 2005 |
| Předmět: |
Receptors
Steroid Neoplasms Hormone-Dependent Histology DNA Repair Base Pair Mismatch Colorectal cancer Pathology and Forensic Medicine medicine Carcinoma Humans beta Catenin Cell growth business.industry Endometrial cancer PTEN Phosphohydrolase Microsatellite instability Cell Biology Genes erbB-2 Normal endometrium medicine.disease Endometrial Neoplasms Serous fluid Disease Progression Cancer research Female Tumor Suppressor Protein p53 business Clear cell Signal Transduction |
| Zdroj: | Cell and Tissue Research. 322:53-61 |
| ISSN: | 1432-0878 0302-766X |
| DOI: | 10.1007/s00441-005-1109-5 |
| Popis: | Endometrial cancer is the most common gynaecological malignancy in the developed world. The majority of cases can be divided into two broad categories based on clinico-pathological and molecular characteristics; Type I oestrogen-dependent with endometrioid morphology and Type II non-oestrogen-dependent with serous papillary or clear cell morphology. As has been described for other malignancies, such as colorectal carcinoma, the transition from normal endometrium to carcinoma is thought to involve a stepwise accumulation of alterations in cellular regulatory pathways leading to dysfunctional cell growth. This article reviews the current knowledge of the molecular changes commonly associated with endometrial cancer and presents possible progression models. |
| Databáze: | OpenAIRE |
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