Enhanced Immunoreceptor Tyrosine-based Activation Motif Signaling is Related to Pathological Bone Resorption During Critical Illness
| Autor: | A. Wauters, Jan Gunst, E Van Herck, Helen C. Owen, S. Van Cromphaut, G Van den Berghe, I. Vanhees, Thomas Janssens |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Critical Illness Endocrinology Diabetes and Metabolism Osteocalcin Clinical Biochemistry Osteoporosis Neovascularization Physiologic Osteoclasts Immunoreceptor Tyrosine-Based Activation Motif 030209 endocrinology & metabolism Biochemistry Bone and Bones Bone resorption Bone remodeling 03 medical and health sciences 0302 clinical medicine Endocrinology Osteogenesis Osteoclast Internal medicine Immunoreceptor tyrosine-based activation motif medicine Animals Humans Bone Resorption 030304 developmental biology Ions 0303 health sciences biology Chemistry Biochemistry (medical) Osteoblast General Medicine medicine.disease medicine.anatomical_structure Gene Expression Regulation RANKL biology.protein Calcium Rabbits Biomarkers Signal Transduction |
| Zdroj: | Hormone and Metabolic Research |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-0033-1351290 |
| Popis: | Prolonged critically ill patients present with distinct alterations in calcium and bone metabolism. Circulating bone formation markers are reduced and bone resorption markers are substantially elevated, indicating an uncoupling between osteoclast and osteoblast activity, possibly resulting in pronounced bone loss, impaired traumatic or surgical fracture healing, and osteoporosis. In addition, we have previously shown that increased circulating osteoclast precursors in critically ill patients result in increased osteoclastogenesis in vitro, possibly through FcγRIII signaling. In the current study, we investigated the effects of sustained critical illness on bone metabolism at the tissue level in a standardized rabbit model of prolonged (7 days), burn injury-induced critical illness. This in vivo model showed a reduction in serum ionized calcium and osteocalcin levels, as is seen in humans. Trabecular area, bone mineral content, and -density were decreased in sick rabbits [by 43% (p |
| Databáze: | OpenAIRE |
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