Back to the future: covalent epitope-based HIV vaccine development
| Autor: | Yasuhiro Nishiyama, Sudhir Paul, Carl V. Hanson, Stephanie Planque, Miguel A. Escobar |
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| Rok vydání: | 2010 |
| Předmět: |
Models
Molecular Biomedical Research Immunology HIV Infections HIV Antibodies HIV Envelope Protein gp120 Article Epitope Epitopes Viral entry Drug Discovery Superantigen Humans HIV vaccine AIDS Vaccines Pharmacology Superantigens biology Immunogenicity env Gene Products Human Immunodeficiency Virus HIV envelope protein Antibodies Neutralizing Virology Protein Structure Tertiary biology.protein Molecular Medicine Antibody |
| Zdroj: | Expert Review of Vaccines. 9:1027-1043 |
| ISSN: | 1744-8395 1476-0584 |
| DOI: | 10.1586/erv.10.77 |
| Popis: | Traditional HIV vaccine approaches have proved ineffective because the immunodominant viral epitopes are mutable and the conserved epitopes necessary for infection are not sufficiently immunogenic. The CD4 binding site expressed by the HIV envelope protein of glycoprotein 120 is essential for viral entry into host cells. In this article, we review the B-cell superantigenic character of the CD4 binding site as the cause of its poor immunogenicity. We summarize evidence supporting development of covalent immunization as the first vaccine strategy with the potential to induce an antibody response to a conserved HIV epitope that neutralizes genetically divergent HIV strains. |
| Databáze: | OpenAIRE |
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