The effect of isoniazid (INH) on Chinese hamster and mouse spermatogonia
| Autor: | Ch. Nautsch, D. Müller, R. Rathenberg, H. Schwegler, I. D. Adler, I. H. Pawlowitzki, Herbert G. Miltenburger, H. Träger, A. Schmaltz |
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| Rok vydání: | 1978 |
| Předmět: |
Chromosome Aberrations
Male medicine.medical_specialty Time Factors Isoniazid Biology bacterial infections and mycoses biology.organism_classification Spermatozoa Spermatogonia Chinese hamster Mice Endocrinology Cricetinae Internal medicine Immunology Genetics medicine Animals Genetics (clinical) medicine.drug |
| Zdroj: | Human Genetics. 42:44-49 |
| ISSN: | 1432-1203 0340-6717 |
| DOI: | 10.1007/bf00291622 |
| Popis: | Acute and chronic treatment of Chinese hamsters and mice with 5, 25 and 125 mg/kg isoniazid (INH) given by oral intubation did not enhance the chromosomal aberration frequencies in spermatogonia. The structural and numerical aberration rates remained in the range of spontaneous events even after the chronic treatment over 12 weeks with 3 x 125 mg/kg INH per week. This dose is much higher than normally used for prevention and therapy in man (3--16 mg/kg). |
| Databáze: | OpenAIRE |
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