Effect of giardiasis combined with low-protein diet on intestinal absorption of glucose and electrolytes in gerbils
| Autor: | Marcelo de Pinho Viana, Sabrina Emanuele de Freitas, Dirce Ribeiro de Oliveira, Elizabeth Lage Borges, Maria Aparecida Gomes |
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| Rok vydání: | 2012 |
| Předmět: |
Giardiasis
Male medicine.medical_specialty Malabsorption medicine.medical_treatment Sodium Potassium Immunology chemistry.chemical_element Absorption (skin) Biology medicine.disease_cause Protein-Energy Malnutrition Intestinal absorption Electrolytes Random Allocation Low-protein diet Internal medicine parasitic diseases medicine Diet Protein-Restricted Giardia lamblia Animals General Medicine medicine.disease Small intestine Infectious Diseases Endocrinology medicine.anatomical_structure Glucose chemistry Intestinal Absorption Parasitology Gerbillinae |
| Zdroj: | Experimental parasitology. 131(4) |
| ISSN: | 1090-2449 |
| Popis: | Studies have shown that symptomatic infection by Giardia lamblia causes acute or chronic diarrhea, dehydration, abdominal pain and malabsorption, leading to undernutrition and weight loss. The aim of the present study was to evaluate the effects of giardiasis and its combination with a low-protein diet on the intestinal absorption of glucose and electrolytes in gerbils. The intestinal absorption of glucose, sodium and potassium was investigated in male gerbils weighing 46-64 g (n≥5). A Tyrode solution containing twice the glucose, sodium and potassium concentration (pH 7.4) was infused through the intestinal loops for 40 min. Glucose absorption was not significantly affected by diet and infection. However, there was a significant increase in sodium absorption in the Giardia-infected group (57.2±6.1, p0.05) in comparison to the control, low-protein diet and low-protein diet+Giardia-infected groups (8.9±6.5, 2.8±11.1 and 0.8±7.9, respectively; p0.05). Moreover, potassium was absorbed in the Giardia-infected group (0.45±0.30), while the other groups exhibited potassium secretion. A low-protein diet and Giardia infection had no influence over glucose absorption. However, Giardia infection increased sodium and potassium uptake, suggesting a compensatory mechanism for maintaining homeostasis after likely hypernatremia and hypokalemia caused by the diarrhea that accompanies giardiasis. |
| Databáze: | OpenAIRE |
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