Proteomic identification of lower apolipoprotein A-I in Alzheimer's disease
| Autor: | Rey Yue Yuan, Sy Jye Leu, Long Shyong Lee, Hsing Cheng Liu, Chaur Jong Hu, Jan-Gowth Chang, Shing Ming Sung |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Proteomics Pathology medicine.medical_specialty Apolipoprotein B Genotype Cognitive Neuroscience Biology Central nervous system disease Degenerative disease Polymorphism (computer science) Alzheimer Disease Reference Values Sequence Analysis Protein Internal medicine medicine Dementia Humans Electrophoresis Gel Two-Dimensional Aged Gel electrophoresis Aged 80 and over Polymorphism Genetic Apolipoprotein A-I Middle Aged medicine.disease Psychiatry and Mental health Endocrinology biology.protein Female Geriatrics and Gerontology Alzheimer's disease Apolipoprotein A-II Biomarkers |
| Zdroj: | Dementia and geriatric cognitive disorders. 21(3) |
| ISSN: | 1420-8008 |
| Popis: | Many researches have been trying to find the potential biomarkers for Alzheimer’s disease (AD). We hereby used the proteomics method to search for protein expression differences in the serum between AD patients and controls. We enrolled 59 AD patients and 74 age- and sex-matched controls in this study. Ten AD patients and 10 controls were selected for proteomic analysis. Apolipoprotein A-I (ApoA-I) was found to have a lower expression in the AD group by a proteomics two-dimensional gel electrophoresis study. We further measured the serum ApoA-I level which was significantly lower in the AD patients (112.29 ± 21.33 mg/dl) in comparison to the controls (144.53 ± 19.91 mg/dl; p < 0.0002). Lower serum ApoA-I levels might be a potential biomarker for AD. |
| Databáze: | OpenAIRE |
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