Serum antibody to lipopolysaccharide antigens of Shigella species among U.S. military personnel deployed to Saudi Arabia and Kuwait during Operations Desert Shield and Desert Storm
| Autor: | K. C. Hyams, T. L. Hale, James R. Murphy, A. L. Bourgeois, J. D. Malone, R. Hawkins |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Diarrhea Lipopolysaccharides Male Microbiology (medical) Serotype Immunoglobulin A Adolescent Clinical Biochemistry Immunology Population Saudi Arabia medicine.disease_cause Microbiology Serology Shigella flexneri Seroepidemiologic Studies parasitic diseases Humans Immunology and Allergy Medicine Shigella Shigella sonnei Seroconversion education Dysentery Bacillary education.field_of_study biology business.industry Hepatitis A biology.organism_classification Antibodies Bacterial Military Personnel Kuwait Data Interpretation Statistical Immunoglobulin G Antibody Formation biology.protein business Research Article |
| Zdroj: | Clinical Diagnostic Laboratory Immunology. 2:700-703 |
| ISSN: | 1098-6588 1071-412X |
| DOI: | 10.1128/cdli.2.6.700-703.1995 |
| Popis: | During Operations Desert Shield and Desert Storm, U.S. troops were at high risk of diarrheal disease due to Shigella spp., particularly Shigella sonnei. In order to better understand the serologic response to Shigella infection, 830 male U.S. combat troops were evaluated before and after the deployment to Saudi Arabia and Kuwait for immunoglobulin A (IgA) and IgG anti-Shigella lipopolysaccharide (LPS) (antibody to S. sonnei form I and Shigella flexneri serotypes 1a, 2a, and 3a) in serum. Just before deployment, 10.3% of the subjects were seropositive for IgA and 18.3% were positive for IgG anti-Shigella LPS. IgA and IgG anti-LPS antibody levels in serum prior to deployment were significantly associated with nonwhite race and ethnicity, birth outside the United States, and antibody to hepatitis A virus and Helicobacter pylori. During the deployment, which lasted for a mean of 131 days, 60% of the subjects reported at least one episode of diarrhea and 15% reported an episode of diarrhea with feverishness; also, 5.5% of the subjects exhibited IgA seroconversion to Shigella LPS and 14.0% exhibited IgG seroconversion. A significant association between the development of diarrheal symptoms and either positive predeployment anti-LPS antibody or seroconversion was not found. These data indicate that in this population of U.S. Desert Storm troops who were at high risk of Shigella infection, there was no apparent relation between IgA or IgG anti-Shigella LPS in serum and diarrheal disease. |
| Databáze: | OpenAIRE |
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