Hippocampal metabolites in asthma and their implications for cognitive function

Autor: Sina Aslan, Juliet L. Kroll, Justin R. Chen, E. Sherwood Brown, Sheenal V. Patel, Thomas Ritz, David A. Khan, Ashton M. Steele, Changho Choi, Amy E. Pinkham
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Magnetic Resonance Spectroscopy
Hippocampus
Hippocampal formation
lcsh:RC346-429
chemistry.chemical_compound
0302 clinical medicine
Cognition
N-acetylaspartate
immune system diseases
Bronchodilator
Structural magnetic resonance imaging
Glutamate receptor
Regular Article
Middle Aged
Magnetic Resonance Imaging
3. Good health
Neurology
lcsh:R858-859.7
Female
Glutamate
Adult
medicine.medical_specialty
1H-MRS
Adolescent
medicine.drug_class
Cognitive Neuroscience
Glutamic Acid
Creatine
Affect (psychology)
lcsh:Computer applications to medicine. Medical informatics
03 medical and health sciences
Young Adult
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
Cognitive Dysfunction
lcsh:Neurology. Diseases of the nervous system
Asthma
Aspartic Acid
medicine.disease
Endocrinology
030228 respiratory system
chemistry
nervous system
Neurology (clinical)
030217 neurology & neurosurgery
Zdroj: NeuroImage: Clinical, Vol 19, Iss, Pp 213-221 (2018)
NeuroImage : Clinical
ISSN: 2213-1582
Popis: Emerging research indicates that individuals with asthma have an increased risk of cognitive impairment, yet the associations of asthma with neural correlates of memory remain relatively unknown. The hippocampus is the predominant neural structure involved in memory, and alterations in the hippocampal metabolic profile are observed in individuals with mild cognitive impairment. We therefore hypothesized that individuals with asthma may have altered hippocampal metabolites compared to healthy controls. Structural magnetic resonance imaging (sMRI) and proton magnetic resonance spectroscopy (1H-MRS) were used to compare hippocampal volume and metabolites of otherwise healthy adults with and without asthma (N = 40), and to study the association of these measures with cognitive function and asthma-related variables. Participants underwent 3-Tesla sMRI and 1H-MRS, with the volume of interest placed in the left hippocampus to measure levels of N-acetylaspartate (NAA), glutamate (Glu), creatine (Cr), and myo-inositol (MI), as indicators of neuronal viability, cellular activity, cellular energy reserve, as well as glial activation. Individuals with asthma had lower hippocampal NAA compared to healthy controls. For all participants, poorer cognitive function was associated with reduced NAA and Glu. For individuals with asthma, poorer cognitive function was associated with reduced disease control. Additionally, short-acting rescue bronchodilator use was associated with significantly lower NAA, and Glu, whereas inhaled corticosteroid use was related to significantly higher Cr and in tendency higher NAA and Glu. All findings controlled for left hippocampal volume, which was not different between groups. These findings highlight that asthma and/or its treatment may affect hippocampal chemistry. It is possible that the observed reductions in hippocampal metabolites in younger individuals with asthma may precede cognitive and hippocampal structural deficits observed in older individuals with asthma.
Highlights • Hippocampal NAA is reduced in younger individuals with asthma compared to healthy controls. • Such reductions in younger individuals with asthma may precede future cognitive impairments. • Asthma medication use was associated with hippocampal metabolites.
Databáze: OpenAIRE
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