Value of Postoperative Radiation Therapy for Regional Control after Dissection in Head and Neck Squamous Cell Carcinoma Cases
| Autor: | Ji-min Cheng, Zhan-Guo He, Bin Di, Yao-Dong Shang, Xiao-Ming Li, Zhen-Feng Tao |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Epidemiology medicine.medical_treatment medicine Humans Neoplasm Invasiveness Postoperative Period Risk factor Survival rate Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Public Health Environmental and Occupational Health Retrospective cohort study Combination chemotherapy Neck dissection Middle Aged Prognosis medicine.disease Combined Modality Therapy Head and neck squamous-cell carcinoma Surgery Survival Rate Radiation therapy Dissection Oncology Head and Neck Neoplasms Lymphatic Metastasis Carcinoma Squamous Cell Neck Dissection Female Radiotherapy Adjuvant Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 14:4273-4278 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2013.14.7.4273 |
| Popis: | Objective: We aimed to define clinicopathologic risk factors associated with regional recurrence (RR) and thus the effectiveness of postoperative radiotherapy (PORT) for neck control for head and neck squamous cell carcinomas (HNSCCs) with differing cervical lymph node status. Methods: A retrospective study was performed in 196 HNSCC patients with pathologically positive neck node (N+) to evaluate the high-risk factors for RR and to define the role of PORT in control after neck dissection and postoperative radiotherapy (PORT). Results: Overall, the RR rate after neck dissection and PORT was 29%. Extracapsular spread (ECS) was confirmed to be the only independent risk factor for RR. There were no significant risk factors associated with RR in the ECS- group. The 5-year disease-specific survival rate was 45%, which descended to 10% with the emergence of RR. Conclusions: ECS remains a determined risk factor for RR after neck dissection and PORT in patients with N+. PORT alone is not adequate for preventing RR in the neck with ECS after neck dissection. More intensive postoperative adjuvant therapies, especially combined chemotherapy and radiotherapy, are needed to prevent regional failure in HNSCC patients with ECS. |
| Databáze: | OpenAIRE |
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