Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder
| Autor: | Antoine Bechara, Liangsuo Ma, Joel L. Steinberg, James M. Bjork, Ponnada A. Narayana, Scott D. Lane, Thomas K. Burroughs, Kathryn A. Cunningham, Thomas R. Kosten, F. Gerard Moeller, Joy M. Schmitz |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Neuroscience (miscellaneous) Hippocampus Hippocampal formation Attentional bias Gyrus Cinguli Article 03 medical and health sciences Cocaine-Related Disorders Random Allocation 0302 clinical medicine Cognition medicine Reaction Time Humans Radiology Nuclear Medicine and imaging Anterior cingulate cortex Brain Mapping medicine.diagnostic_test business.industry Middle Aged Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Cue reactivity Stroop Test Cocaine use Female Cues Nerve Net Functional magnetic resonance imaging business Neuroscience 030217 neurology & neurosurgery Photic Stimulation Stroop effect |
| Zdroj: | Psychiatry research. Neuroimaging. 271 |
| ISSN: | 1872-7506 |
| Popis: | Drug-related attentional bias may have significant implications for the treatment of cocaine use disorder (CocUD). However, the neurobiology of attentional bias is not completely understood. This study employed dynamic causal modeling (DCM) to conduct an analysis of effective (directional) connectivity involved in drug-related attentional bias in treatment-seeking CocUD subjects. The DCM analysis was conducted based on functional magnetic resonance imaging (fMRI) data acquired from fifteen CocUD subjects while performing a cocaine-word Stroop task, during which blocks of Cocaine Words (CW) and Neutral Words (NW) alternated. There was no significant attentional bias at group level. Although no significant brain activation was found, the DCM analysis found that, relative to the NW, the CW caused a significant increase in the strength of the right (R) anterior cingulate cortex (ACC) to R hippocampus effective connectivity. Greater increase of this connectivity was associated with greater CW reaction time (relative to NW reaction time). The increased strength of R ACC to R hippocampus connectivity may reflect ACC activation of hippocampal memories related to drug use, which was triggered by the drug cues. This circuit could be a potential target for therapeutics in CocUD patients. No significant change was found in the other modeled connectivities. |
| Databáze: | OpenAIRE |
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