Living supramolecular polymerization realized through a biomimetic approach
| Autor: | Kazunori Sugiyasu, Sadaki Samitsu, Soichiro Ogi, Swarup Manna, Masayuki Takeuchi |
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| Rok vydání: | 2014 |
| Předmět: |
Models
Molecular inorganic chemicals Biomimetic materials Molecular Structure Macromolecular Substances Thermodynamic equilibrium General Chemical Engineering technology industry and agriculture Supramolecular chemistry Nanotechnology macromolecular substances General Chemistry Porphyrin Polymerization chemistry.chemical_compound Monomer chemistry Biomimetic Materials Biomimetics biological sciences Polymer chemistry Molecule lipids (amino acids peptides and proteins) Derivative (chemistry) |
| Zdroj: | Nature Chemistry. 6:188-195 |
| ISSN: | 1755-4349 1755-4330 |
| DOI: | 10.1038/nchem.1849 |
| Popis: | Various conventional reactions in polymer chemistry have been translated to the supramolecular domain, yet it has remained challenging to devise living supramolecular polymerization. To achieve this, self-organization occurring far from thermodynamic equilibrium--ubiquitously observed in nature--must take place. Prion infection is one example that can be observed in biological systems. Here, we present an 'artificial infection' process in which porphyrin-based monomers assemble into nanoparticles, and are then converted into nanofibres in the presence of an aliquot of the nanofibre, which acts as a 'pathogen'. We have investigated the assembly phenomenon using isodesmic and cooperative models and found that it occurs through a delicate interplay of these two aggregation pathways. Using this understanding of the mechanism taking place, we have designed a living supramolecular polymerization of the porphyrin-based monomers. Despite the fact that the polymerization is non-covalent, the reaction kinetics are analogous to that of conventional chain growth polymerization, and the supramolecular polymers were synthesized with controlled length and narrow polydispersity. |
| Databáze: | OpenAIRE |
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