Association Between Atrial, Ventricular and Vascular Morphofunctional Alterations in Rheumatoid Arthritis
| Autor: | I. Boggioni, Carlo Valena, Alessandro Maloberti, Marijana Tadic, Guido Grassi, Marta Riva, Paolo Villa, Maria Rosa Pozzi |
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| Přispěvatelé: | Maloberti, A, Riva, M, Tadic, M, Valena, C, Villa, P, Boggioni, I, Pozzi, M, Grassi, G |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Diastolic function Diastole Blood Pressure Atrial Function Right 030204 cardiovascular system & hematology Ventricular Function Left Arthritis Rheumatoid 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Pharmacotherapy Predictive Value of Tests Left atrial Internal medicine Internal Medicine medicine Humans Rheumatoid arthriti Aged 030203 arthritis & rheumatology business.industry Middle Aged Left ventricle medicine.disease Echocardiography Doppler Arterial stiffne Cross-Sectional Studies Blood pressure Antirheumatic Agents Case-Control Studies Left atrium Rheumatoid arthritis Ventricular Function Right Cardiology Arterial stiffness Atrial Function Left Female Methotrexate Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | High Blood Pressure & Cardiovascular Prevention. 25:97-104 |
| ISSN: | 1179-1985 1120-9879 |
| DOI: | 10.1007/s40292-017-0246-8 |
| Popis: | Introduction: Rheumatoid arthritis (RA) represents a risk of non-fatal and cardiovascular events. The aim of the present study was to evaluate simultaneously left and right atrial and ventricular function, as well as arterial stiffness, in RA patients. Methods: This cross-sectional study included 55 consecutive RA patients and 55 healthy age and gender-matched controls. Blood pressure and arterial stiffness were assessed in all participants, who also underwent a complete echocardiographic examination. Results: RA patients were treated with steroid therapy (52.7%), methotrexate (66.6%) and biological therapy (54.5%). Disease activity score revealed low average RA activity. Augmentation index was significantly higher in RA patients (32.2 ± 8.6 vs. 28.4 ± 8.9%, P = 0.02). Left atrial volume was also higher among RA patients (23.1 ± 8.2 vs. 20.1 ± 7.1 ml/m2, P = 0.04), whereas mitral and tricuspid E/A ratios were significantly lower in RA individuals (0.90 ± 0.24 vs. 1.03 ± 0.35, P = 0.02; 1.07 ± 0.31 vs. 1.27 ± 0.35, P = 0.003, respectively). Tissue Doppler systolic and diastolic velocities were similar between the observed groups. Arterial stiffness index showed significant correlation with disease duration (r = 0.29; P = 0.03). Tissue Doppler-derived transmitral late diastolic velocity (A′) showed significant correlation with index of disease activity in the RA patients. Conclusions: Our results showed that left and right ventricular diastolic function and arterial stiffness were significantly deteriorated in the RA patients comparing with controls. The assessment of left and right ventricular diastolic function, as well as vascular function, should be an essential part of clinical evaluation in the RA patients. |
| Databáze: | OpenAIRE |
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