Second primary malignancies in head and neck cancer patients: high prevalence of curable-stage disease
| Autor: | Klaus Jung, Sabine Sennhenn-Kirchner, Hendrik A. Wolff, CF Hess, Hans Christiansen, Annegret Müller-Dornieden, Marc Hinterthaner, W. Körber, C. Engelke, K. Marten-Engelke, C.R.M. Wolff, Ralph M.W. Roedel |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Risk Assessment Neoplasms Multiple Primary Germany otorhinolaryngologic diseases Carcinoma medicine Prevalence Humans Radiology Nuclear Medicine and imaging Stage (cooking) Esophagus Survival rate Aged medicine.diagnostic_test business.industry Squamous Cell Carcinoma of Head and Neck Head and neck cancer Middle Aged medicine.disease Endoscopy Surgery Radiation therapy Survival Rate stomatognathic diseases medicine.anatomical_structure Treatment Outcome Oncology Head and Neck Neoplasms Cohort Carcinoma Squamous Cell Radiology Radiotherapy Conformal business |
| Zdroj: | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]. 189(10) |
| ISSN: | 1439-099X |
| Popis: | Patients treated for squamous cell carcinoma of the head and neck (HNSCC) carry a high risk of second primary malignancies (SPM). Recently, computed tomography (CT) of the chest was shown to significantly decrease the risk of death due to bronchial carcinoma (BC) in a cohort of smokers whose risk of BC is increased but might be lower than that of patients previously treated for HNSCC. Thus, the present study evaluated the potential benefit of CT and other examinations in the detection of SPM in HNSCC patients. Between July 2008 and November 2011, 118 participants underwent a prospective, systematic examination for SPM (13 women, 105 men, median age 62 years). All patients had been previously treated for HNSCC and showed no recurrence or distant metastases at the time of the study start. CT scans, ear–nose–throat endoscopy, and endoscopy of the esophagus and stomach were performed. Overall, 33 suspicious findings were clarified by additional investigations. In all, 26 SPM were confirmed in 21 of 118 patients (18 %; 10 lung, 7 HNSCC, 3 gastrointestinal, 1 renal). Eighteen of these 21 patients (86 %) underwent therapy with curative intent. The examinations revealed a high prevalence of curable stage SPM in HNSCC patients. Adapting a surveillance scheme including a chest CT is recommended. |
| Databáze: | OpenAIRE |
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