Trichosporon inkin Esophagitis: An Uncommon Disease in a Patient with Pulmonary Cancer
| Autor: | Vanessa Karina Alves da Silva, Rejane Pereira Neves, Aline Mary de Almeida Farias, Ana Botler Wilheim, Reginaldo Gonçalves de Lima Neto, Nadyr Pedi, Patrícia Cariolano de Oliveira, Danielle Patrícia Cerqueira Macêdo, Suanni Lemos de Andrade, Neiva Tinti de Oliveira |
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| Rok vydání: | 2010 |
| Předmět: |
Azoles
medicine.medical_specialty Pathology Antifungal Agents Lung Neoplasms Neutropenia Veterinary (miscellaneous) Microbial Sensitivity Tests Polyenes Disease Applied Microbiology and Biotechnology Microbiology Immunocompromised Host Esophagus Medical microbiology Trichosporon Pulmonary cancer Esophagitis Humans Medicine Treatment Failure Severe neutropenia chemistry.chemical_classification Microscopy business.industry Middle Aged medicine.disease Dermatology Mycoses chemistry Trichosporon inkin Azole Female Esophagoscopy business Agronomy and Crop Science Fluconazole medicine.drug |
| Zdroj: | Mycopathologia. 171:279-283 |
| ISSN: | 1573-0832 0301-486X |
| Popis: | Trichosporon species are usually opportunistic pathogens. Here, we present a case of esophagitis caused by T. inkin in a 54-year-old woman with pulmonary cancer and severe neutropenia in whom the susceptibility profile of the isolate against azoles and polyenes was verified. The patient was diagnosed with esophagitis grade I of Wilcox, presenting scattered whitish plaques and exudates in upper two-thirds of the esophageal mucosa. Antifungal therapy involving oral fluconazole (150 mg/day for 14 days) was ineffective. In vitro, the isolate showed no resistance to this azole and sensitivity to amphotericin B. Since T. inkin is of growing importance as an agent of invasive infections in immunocompromised patients, we stress that the diagnosis of esophagitis by this species should be followed by an assessment of the therapeutic sensitivity of the strain involved. |
| Databáze: | OpenAIRE |
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