Russell body duodenitis: A histopathological and molecular approach to a rare clinical entity
| Autor: | Alberto E. Paniz Mondolfi, Maria Samuel, Denisa Slova, David M. Feldman, Judith Kikhney, Alexander Filatov, Neil D. Theise, Annette Moter |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
DNA
Bacterial Pathology medicine.medical_specialty Plasma Cells Russell bodies Biology Pathology and Forensic Medicine Immune system Duodenitis Eosinophilic medicine Humans Intestinal Mucosa In Situ Hybridization Fluorescence Aged Inclusion Bodies Helicobacter pylori Endoplasmic reticulum Cell Biology medicine.disease biology.organism_classification Immunology biology.protein Female Antibody Gastritis medicine.symptom |
| Zdroj: | Pathology - Research and Practice. 208:415-419 |
| ISSN: | 0344-0338 |
| DOI: | 10.1016/j.prp.2012.05.007 |
| Popis: | Russell bodies are pink eosinophilic accumulations within plasma cells. To date, two hypotheses have attempted to elucidate the biological events behind the formation of these bodies. One theory sustains that such bodies constitute cytoplasmic accumulation of immunoglobulin derivatives contained in the perinuclear cistern of the smooth endoplasmic reticulum because of an increased synthesis or altered secretion. On the other hand, since its initial description in the medical literature, several authors have attributed the formation of such bodies to the presence of microorganisms such as in the case of Russell body gastritis and its association to Helicobacter pylori infection. In an attempt to possibly characterize the presence of an infectious organism, we performed a thorough biomolecular analysis on a case of a 69-year-old female presenting with Russell body duodenitis which, to the best of our knowledge, constitutes the second report of this clinical entity in the English literature. In light that the events behind formation of such bodies in H. pylori-negative individuals remain unclear, we hypothesize on the possible pathways that could have led to their reactive mechanical and immune derivation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect