Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience
| Autor: | Patrick S. Kamath, Manuel Bonfim Braga Neto, Taofic Mounajjed, Douglas A. Simonetto, Dharma Sunjaya, Guilherme Piovezani Ramos, Vijay H. Shah, Ryan J. Lennon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Cirrhosis Hepatic plate atrophy Gastroenterology 03 medical and health sciences 0302 clinical medicine Atrophy Retrospective Study Internal medicine Ascites medicine Hepatology medicine.diagnostic_test business.industry Sinusoidal obstruction syndrome Sinusoidal dilatation medicine.disease Congestive hepatopathy 030220 oncology & carcinogenesis Heart failure Liver biopsy Portal hypertension 030211 gastroenterology & hepatology medicine.symptom business Nodular regenerative hyperplasia |
| Zdroj: | World Journal of Hepatology |
| ISSN: | 1948-5182 |
| Popis: | AIM To characterize isolated non-obstructive sinusoidal dilatation (SD) by identifying associated conditions, laboratory findings, and histological patterns. METHODS Retrospectively reviewed 491 patients with SD between 1995 and 2015. Patients with obstruction at the level of the small/large hepatic veins, portal veins, or right-sided heart failure were excluded along with history of cirrhosis, hepatic malignancy, liver transplant, or absence of electrocardiogram/cardiac echocardiogram. Liver histology was reviewed for extent of SD, fibrosis, red blood cell extravasation, nodular regenerative hyperplasia, hepatic peliosis, and hepatocellular plate atrophy (HPA). RESULTS We identified 88 patients with non-obstructive SD. Inflammatory conditions (32%) were the most common cause. The most common pattern of liver abnormalities was cholestatic (76%). Majority (78%) had localized SD to Zone III. Medication-related SD had higher proportion of portal hypertension (53%), ascites (58%), and median AST (113 U/L) and ALT (90 U/L) levels. Nineteen patients in our study died within one-year after diagnosis of SD, majority from complications related to underlying diseases. CONCLUSION Significant proportion of SD and HPA exist without impaired hepatic venous outflow. Isolated SD on liver biopsy, in the absence of congestive hepatopathy, requires further evaluation and portal hypertension should be rule out. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|