Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder—A Randomized, Controlled 12-Month Trial
| Autor: | Dana Laake, Elena L. Pollard, Elizabeth Geis, Valeria Fimbres, Devon M. Coleman, Eva Gehn, Robert Hellmers, Rebecca L. Adams, David Quig, James B. Adams, Kefeng Li, Julie Ingram, Robert K. Naviaux, Tapan Audhya, Julie S. Matthews, Jessica Mitchell, Jane C. Naviaux |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male and promotion of well-being Time Factors Autism Spectrum Disorder Autism Intelligence Child Behavior Treatment and control groups chemistry.chemical_compound 0302 clinical medicine Child Development Medicine Single-Blind Method Child Pediatric Nutrition and Dietetics Arizona Caseins minerals Middle Aged vitamins Mental Health Treatment Outcome Autism spectrum disorder 6.1 Pharmaceuticals Child Preschool Soybean Proteins Female Epsom salts Diet Healthy lcsh:Nutrition. Foods and food supply Neurotypical medicine.drug Vitamin Adult medicine.medical_specialty Adolescent Intellectual and Developmental Disabilities (IDD) Clinical Trials and Supportive Activities autism Nutritional Status Protein-Restricted lcsh:TX341-641 essential fatty acids autism spectrum disorder carnitine digestive enzymes Article 03 medical and health sciences Diet Gluten-Free Young Adult Food Sciences Clinical Research Internal medicine Intervention (counseling) Complementary and Integrative Health Diet Protein-Restricted Humans Carnitine Preschool 3.3 Nutrition and chemoprevention Metabolic and endocrine Nutrition Coenzyme Q10 Healthy business.industry Prevention Evaluation of treatments and therapeutic interventions Adolescent Development Prevention of disease and conditions medicine.disease Diet Brain Disorders 030104 developmental biology chemistry Adolescent Behavior Dietary Supplements Gluten-Free business 030217 neurology & neurosurgery Food Science |
| Zdroj: | Nutrients; Volume 10; Issue 3; Pages: 369 Nutrients Nutrients, Vol 10, Iss 3, p 369 (2018) Nutrients, vol 10, iss 3 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu10030369 |
| Popis: | This study involved a randomized, controlled, single-blind 12-month treatment study of a comprehensive nutritional and dietary intervention. Participants were 67 children and adults with autism spectrum disorder (ASD) ages 3-58 years from Arizona and 50 non-sibling neurotypical controls of similar age and gender. Treatment began with a special vitamin/mineral supplement, and additional treatments were added sequentially, including essential fatty acids, Epsom salt baths, carnitine, digestive enzymes, and a healthy gluten-free, casein-free, soy-free (HGCSF) diet. There was a significant improvement in nonverbal intellectual ability in the treatment group compared to the non-treatment group (+6.7 ± 11 IQ points vs. -0.6 ± 11 IQ points, p = 0.009) based on a blinded clinical assessment. Based on semi-blinded assessment, the treatment group, compared to the non-treatment group, had significantly greater improvement in autism symptoms and developmental age. The treatment group had significantly greater increases in EPA, DHA, carnitine, and vitamins A, B2, B5, B6, B12, folic acid, and Coenzyme Q10. The positive results of this study suggest that a comprehensive nutritional and dietary intervention is effective at improving nutritional status, non-verbal IQ, autism symptoms, and other symptoms in most individuals with ASD. Parents reported that the vitamin/mineral supplements, essential fatty acids, and HGCSF diet were the most beneficial. |
| Databáze: | OpenAIRE |
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