Environmental Programming of Adult Foraging Behavior in C. elegans
| Autor: | Michael Hendricks, Kai Homer, Sabrina Quilez, Sreeparna Pradhan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Foraging Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Behavioral plasticity Biological neural network Animals Allele Caenorhabditis elegans Caenorhabditis elegans Proteins Domestication Sensory cue 030304 developmental biology 0303 health sciences Life span Feeding Behavior Globins Phenotype 030104 developmental biology Evolutionary biology Developmental plasticity Food Deprivation General Agricultural and Biological Sciences 030217 neurology & neurosurgery |
| Zdroj: | Current Biology. 29:2867-2879.e4 |
| ISSN: | 0960-9822 |
| DOI: | 10.1016/j.cub.2019.07.045 |
| Popis: | Summary Foraging strategies should be tuned to the expected distribution of resources in the environment. Tuning can occur over generations and lead to genetic differences in innate foraging behavior or over shorter timescales within an individual's lifespan. Both genetically encoded and experience-based strategies are implemented by neural circuits that respond to environmental cues and track internal states. Caenorhabditis elegans exhibit both between-strain genetic differences and within-strain plasticity in foraging. In individuals, changes in foraging are usually short term and based on recent experience. Here, we tested whether developmental experience could permanently alter foraging. We found that, in most wild strains, early-life starvation led to "cautious" foraging strategies, in which exploration is reduced, and these behavioral changes are associated with altered dynamics in a locomotory circuit. Possessing either the derived (domestication-associated) or ancestral allele of the neuroglobin glb-5 determines foraging plasticity. Overall, we show that C. elegans exhibit adaptive developmental plasticity that affects multiple aspects of foraging behavior and leads to changes in a core navigation circuit and that innate foraging traits and plasticity in those traits are genetically separable. Video Abstract |
| Databáze: | OpenAIRE |
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