Separation and study of the range of plasminogen isoforms in patients with prostate cancer
| Autor: | E. N. Cherkasova, N. V. Boyko, E. F. Shin, Mikhail Kogan, M. B. Chibichian, D. I. Vodolazhsky, A. Yu. Golikov, V. A. Tarasov, D. V. Zimakov, D. G. Matishov, T. N. Belova, Sergei A. Moshkovskii |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Gene isoform Molecular mass Chemistry Prostatic Neoplasms Plasminogen General Medicine Middle Aged medicine.disease Biochemistry Molecular biology Prostate cancer Matrix-assisted laser desorption/ionization Affinity chromatography Two dimensional electrophoresis Blood plasma medicine Humans Protein Isoforms In patient Aged |
| Zdroj: | Biochemistry (Moscow). 77:1065-1071 |
| ISSN: | 1608-3040 0006-2979 |
| DOI: | 10.1134/s0006297912090143 |
| Popis: | Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in various stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and higher pI values compared to isoforms found in the control group. |
| Databáze: | OpenAIRE |
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