Augmentation of Tendon Healing in an Intraarticular Bone Tunnel with Use of a Bone Growth Factor
Autor: | Aruna M. Seneviratne, Scott A. Rodeo, Kyle Anderson, Brent Atkinson, Kazutaka Izawa, Hollis G. Potter |
---|---|
Rok vydání: | 2001 |
Předmět: |
medicine.medical_specialty
medicine.medical_treatment Anterior cruciate ligament Physical Therapy Sports Therapy and Rehabilitation Tendons 03 medical and health sciences 0302 clinical medicine medicine Animals Orthopedics and Sports Medicine Wound Healing 030222 orthopedics Lagomorpha medicine.diagnostic_test biology business.industry Anterior Cruciate Ligament Injuries Growth factor Magnetic resonance imaging 030229 sport sciences Anatomy biology.organism_classification Magnetic Resonance Imaging Biomechanical Phenomena Hindlimb Tendon Surgery Transplantation Apposition medicine.anatomical_structure Bone growth factor Bone Morphogenetic Proteins Rabbits business |
Zdroj: | The American Journal of Sports Medicine. 29:689-698 |
ISSN: | 1552-3365 0363-5465 |
Popis: | We hypothesized that an exogenous bone growth factor could augment healing of a tendon graft in a bone tunnel in a rabbit anterior cruciate ligament-reconstruction model. Seventy rabbits underwent bilateral anterior cruciate ligament reconstructions with a semitendinosus tendon graft. One limb received a collagen sponge carrier vehicle containing a mixture of bone-derived proteins while the contralateral limb was treated with either no sponge or a sponge without bone-derived proteins. The reconstruction was evaluated at 2, 4, or 8 weeks with histologic, biomechanical, and magnetic resonance imaging analysis. Histologic analysis demonstrated that specimens treated with bone-derived proteins had a more consistent, dense interface tissue and closer apposition of new bone to the graft, with occasional formation of a fibrocartilaginous interface, when compared with control specimens. The treated specimens had significantly higher load-to-failure rates than did control specimens. Treatment with bone-derived proteins resulted in an average increase in tensile strength of 65%. The treated specimens were stronger than control specimens at each time point, but the difference was greatest at 8 weeks. On the basis of signal characteristics and new bone formation, magnetic resonance imaging was useful for predicting which limb was treated, the site of failure, and the limbs with higher load-to-failure values. This study demonstrates the potential for augmenting tendon healing in an intraarticular bone tunnel using an osteoinductive growth factor. |
Databáze: | OpenAIRE |
Externí odkaz: |