Abnormal T-cell costimulation by proteins of the extracellular matrix in human renal allografting
| Autor: | T. Mrowiec, Stepień-Sopniewska B, Leszek Paczek, Andrzej Górski |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Graft Rejection
Endothelium Immunology Integrin Receptors Cell Surface Lymphocyte Activation Extracellular matrix Postoperative Complications Renal Artery T-Lymphocyte Subsets Cyclosporin a Azathioprine Humans Medicine Receptor Inflammation Arteritis Extracellular Matrix Proteins Kidney biology business.industry Kidney Transplantation Fibronectins Cell biology Transplantation Fibronectin medicine.anatomical_structure Cyclosporine biology.protein Prednisone Collagen Endothelium Vascular business |
| Zdroj: | Research in Immunology. 144:305-309 |
| ISSN: | 0923-2494 |
| DOI: | 10.1016/s0923-2494(93)80071-6 |
| Popis: | Summary T cells interact with extracellular matrix (ECM) proteins as they pass through the endothelium and move about in various microenvironments. Recent data indicate that such proteins provide strong costimulation to CD3-TCR-complex-mediated T-cell activation. Thus, ECM proteins can regulate T-cell responses via their integrin and non-integrin receptors. We have shown that the costimulating activity of interstitial ECM proteins (collagen type I, fibronectin) is abolished in renal allograft recipients treated with cyclosporin A (CsA) but not azathioprine. In contrast, cyclosporin treatment does not affect potent costimulation provided by the major component of basement membranes, collagen type IV. We suggest that these disturbances in T-cell interactions with ECM proteins caused by CsA therapy may contribute to cyclosporin-induced transplant arteriosclerosis. |
| Databáze: | OpenAIRE |
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