Cardiotrophin-1: A new predictor of atrial fibrillation relapses after successful cardioversion
Autor: | Burak Pamukcu, Goksel Guz, Kamil Adalet, Cenk Eray Yildiz, Ahmet Kaya Bilge, Ibrahim Altun, Ümit Türkoğlu, Akar Yilmaz, Selda Can Arkaya |
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Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Electric Countershock Cardioversion cardiotrophin-1 Electrocardiography cardioversion Predictive Value of Tests Recurrence medicine.artery Internal medicine Atrial Fibrillation Medicine Humans Sinus rhythm Aged lcsh:R5-920 Ejection fraction medicine.diagnostic_test business.industry Atrial fibrillation General Medicine Middle Aged medicine.disease medicine.anatomical_structure ROC Curve Ventricle Anesthesia Case-Control Studies Pulmonary artery Ambulatory Cardiology Cytokines Female business lcsh:Medicine (General) Research Article |
Zdroj: | ResearcherID Bosnian Journal of Basic Medical Sciences, Vol 15, Iss 3 (2015) |
Popis: | We aimed to investigate whether or not cardiotrophin-1 (CT-1) can be used as a predictor of sinus rhythm constancy in patients with atrial fibrillation (AF) converted to sinus rhythm. Thirty two patients with AF (48-78 years), without any structural heart disease were enrolled for the study. The control group consisted of 32, age and gender matched healthy persons. Measurements of CT-1 were made after transthoracic and transesophageal echocardiography prior to cardioversion (CV). Relapses of AF were investigated by monthly electrocardiograms (ECGs) and ambulatory ECGs at 1st, 3rd, and 6th month. At the end of 6th month, measurements of CT-1 were repeated. At the beginning patients with AF had increased CT-1 levels when compared to controls (0.94 ± 0.32 pg/mL vs. 0.30 ± 0.12 pg/mL, [p < 0.001]). At the end of follow-up of the 32 patients, 17 (53%) had AF relapse. Age, initial duration of AF, left ventricle diameters, ejection fraction, left atrium appendix flow rates were similar among patients with and without AF relapse. However, basal left atrium diameter (4.24 ± 0.14 cm vs. 4.04 ± 0.22 cm, p = 0.005), pulmonary artery pressure (32.82 ± 5 vs. 28.60 ± 6.23 mmHg, p = 0.004) and CT-1 values (1.08 ± 0.37 vs. 0.82 ± 0.16 pg/mL, p = 0.02) were significantly increased in patients with AF relapse. Furthermore, patients with relapsed AF had higher CT-1 levels at 6th month when compared to those in sinus rhythm (1.00 ± 0.40 vs. 0.71 ± 0.23 pg/mL). We conclude that post-CV, AF relapses are more frequent among patients with increased baseline CT-1 levels, and CT-1 may be a potential predictor of AF relapse. |
Databáze: | OpenAIRE |
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