TAZ stimulates liver regeneration through interleukin‐6–induced hepatocyte proliferation and inhibition of cell death after liver injury
| Autor: | Jeong Ho Hong, Ee Hyun Kim, Jun Ha Hwang, Ho Taek Oh, Jung I Park, Mi Gyeong Jeong, A. Rum Kim, Eun Sook Hwang, Kyungmin Kim |
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| Rok vydání: | 2019 |
| Předmět: |
Male
STAT3 Transcription Factor 0301 basic medicine MAPK/ERK pathway Programmed cell death medicine.medical_treatment Apoptosis Biochemistry Mice 03 medical and health sciences 0302 clinical medicine Genetics medicine Animals Hepatectomy Extracellular Signal-Regulated MAP Kinases Carbon Tetrachloride Molecular Biology Alleles Adaptor Proteins Signal Transducing Cell Proliferation Mice Knockout Liver injury Cell Death Interleukin-6 Chemistry medicine.disease Liver regeneration Liver Regeneration Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Cytokine Liver Hepatocyte Hepatocytes Trans-Activators Hepatic stellate cell Cancer research STAT protein Proto-Oncogene Proteins c-akt 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | The FASEB Journal. 33:5914-5923 |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fj.201801256rr |
| Popis: | In response to liver injury, the liver undergoes a regeneration process to retain its mass and function. However, the regeneration mechanism has not been fully clarified. This study investigated the role of transcriptional coactivator with PDZ-binding motif (TAZ), a Hippo-signaling effector, in liver regeneration. We observed that TAZ stimulates liver regeneration after liver injury. After partial hepatectomy (PHx) or carbon tetrachloride damage, TAZ was required for liver regeneration to increase hepatic cell proliferation and resist hepatic apoptosis, which were decreased in liver-specific TAZ knockout (LKO) mice. TAZ stimulated macrophage infiltration, resulting in IL-6 production, which induced liver regeneration. In LKO mice, IL-6-induced activation of signal transducer and activator of transcription 3, ERK, and PKB was decreased. We also observed that periductal fibrogenesis was significantly increased in LKO mice during liver regeneration after PHx, which was caused by increased hepatic apoptosis. Our results suggest that TAZ stimulates liver regeneration through IL-6-induced hepatocyte proliferation and inhibition of cell death after liver injury.-Kim, A. R., Park, J. I., Oh, H. T., Kim, K. M., Hwang, J.-H., Jeong, M. G., Kim, E.-H., Hwang, E. S., Hong, J.-H. TAZ stimulates liver regeneration through interleukin-6-induced hepatocyte proliferation and inhibition of cell death after liver injury. |
| Databáze: | OpenAIRE |
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