Central Nervous System Plasticity Influences Language and Cognitive Recovery in Adult Glioma
| Autor: | Nyle Almeida, Shawn L. Hervey-Jumper, Saritha Krishna, Sofia Kakaizada, David Brang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Central Nervous System Central nervous system 03 medical and health sciences 0302 clinical medicine Cognition Glioma Aphasia Medicine Humans 030304 developmental biology Language 0303 health sciences Brain Mapping business.industry Tumor biology Brain Neoplasms Neurogenesis Surgical Management of Eloquent Area Tumors Network dynamics Cognitive network medicine.disease nervous system diseases medicine.anatomical_structure Quality of Life Surgery Neurology (clinical) medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurosurgery |
| ISSN: | 1524-4040 |
| Popis: | Gliomas exist within the framework of complex neuronal circuitry in which network dynamics influence both tumor biology and cognition. The generalized impairment of cognition or loss of language function is a common occurrence for glioma patients. The interface between intrinsic brain tumors such as gliomas and functional cognitive networks are poorly understood. The ability to communicate effectively is critically important for receiving oncological therapies and maintaining a high quality of life. Although the propensity of gliomas to infiltrate cortical and subcortical structures and disrupt key anatomic language pathways is well documented, there is new evidence offering insight into the network and cellular mechanisms underpinning glioma-related aphasia and aphasia recovery. In this review, we will outline the current understanding of the mechanisms of cognitive dysfunction and recovery, using aphasia as an illustrative model. |
| Databáze: | OpenAIRE |
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