Liquid crystalline glycosteroids and acyl steroid glycosides (ASG)
| Autor: | Fahima Ali-Rachedi, John W. Goodby, Stéphane Chambert, Edward J. Davis, Laurent Soulère, Mohammed Ahmar, Nuno M. Xavier, Zonglong Yang, Yves Queneau, Rui Xu, Stephen J. Cowling, Grahame Mackenzie |
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| Přispěvatelé: | KDDI R&D Laboratories Inc. [Saitama], Chimie Organique et Bioorganique (COB), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Department of Chemistry, University of Hull |
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Materials science [CHIM.ORGA]Chemical Sciences/Organic chemistry 010405 organic chemistry Stereochemistry medicine.medical_treatment Glycoside General Chemistry 010402 general chemistry Condensed Matter Physics 01 natural sciences 0104 chemical sciences Steroid Glycolipid Membrane chemistry Liquid crystal medicine Molecule Moiety Organic chemistry General Materials Science ComputingMilieux_MISCELLANEOUS Alkyl |
| Zdroj: | Liquid Crystals Liquid Crystals, Taylor & Francis, 2017, pp.1-19. ⟨10.1080/02678292.2017.1346211⟩ |
| ISSN: | 1366-5855 0267-8292 |
| Popis: | As part of our studies on glycolipidic liquid crystals, we have investigated some molecules comprising a steroid moiety. These systems can exhibit several types of structures depending on their polarity pattern based on the number of polar and non-polar moieties and their resulting molecular shape. Therefore, to aid describing such systems, we have proposed a specific classification based on this polarity pattern. Many compounds in this family are natural products, which possess important biological properties. Some of the compounds have bolaphilic structures, with both a steroid and a fatty alkyl chain attached to the carbohydrate moiety, such as either the β-galactoside BbGL-1 or the α-glucoside α-CAG that are found in the membranes of the pathogens Borrelia burgdorferi and Helicobacter pylori, respectively. In this account, after a brief introduction on liquid crystalline glycolipids, we focus on carbohydrate–steroid hybrids, summarising our previous work on glycosteroids prepared by the CMGL-synthon strategy, and reporting our preliminary results on the thermotropic behaviour of acyl steroid glycosides (ASG), namely cholesteryl 6-O-acyl-β-gluco- and -galacto-pyranosides. |
| Databáze: | OpenAIRE |
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