Intraoral pigmented low-grade adenocarcinoma, not otherwise specified: case report and immunohistochemical study
| Autor: | Luciana Yamamoto Almeida, Jorge Esquiche León, Alfredo Ribeiro-Silva, Jessica Luana Dos Santos, Cássio Edvard Sverzut, Albina Altemani, Lucas Ribeiro Teixeira, Alexandre Elias Trivellato |
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| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty GLÂNDULAS SALIVARES Perineural invasion Case Report Vimentin Adenocarcinoma Stain Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Parenchyma Biomarkers Tumor medicine Humans Hyaline Melanins Salivary gland biology Pigmentation Chemistry 030206 dentistry Middle Aged Salivary Gland Neoplasms medicine.disease Immunohistochemistry medicine.anatomical_structure Oncology Otorhinolaryngology 030220 oncology & carcinogenesis biology.protein Female |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Salivary adenocarcinoma, not otherwise specified (AdCaNOS) is a rare malignant tumor with potential diagnostic challenge, which mainly affects the parotid glands; however, the minor salivary glands can also be involved by AdCaNOS. This paper reports a case of a 45-year-old Afro-descendant woman complaining of a slow-growing mass with 6 months of evolution in the left superior vestibular fornix. Microscopic examination revealed an infiltrative epithelial neoplasm composed of predominantly solid growth pattern, arranged in a lobular configuration, admixed with glandular or ductal structures. Perineural invasion was evident. The tumor cells were polygonal or oval showing focally mild nuclear pleomorphism, and eosinophilic or clear cytoplasm. Notably, some areas exhibited intracytoplasmic pigment granules mainly in non-luminal cells, as well as sebaceous-like cells, discrete hyaline material deposition and foci of infiltration of residual salivary gland parenchyma. Tumor cells were negative for PAS, mucicarmine and Alcian blue stains. By immunohistochemistry, the tumor cells were diffuse and strongly positive for pan-cytokeratin (CK) AE1/AE3, 34betaE12 CK, vimentin, p63 and S100. CK7 and EMA strongly highlighted the ductal structures. Solid areas also showed diffuse and moderate expression of CD56. Podoplanin (D2-40), GFAP and Calponin, followed by DOG-1, were focally positive; whereas CK20, α-SMA, h-Caldesmon, CD57, ERBB2/HER2 and p53 were negative. Ki-67 was |
| Databáze: | OpenAIRE |
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