Manganese Retention in Rat Brain
| Autor: | J. Svihalkova, Jana Knotková, E. Svandová, Max Vojtíšek, Ζ. Paduanová |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Aging
medicine.medical_specialty Health (social science) Intratracheal instillation medicine.medical_treatment chemistry.chemical_element Manganese Internal medicine Intubation Intratracheal medicine Animals Rats Wistar Saline Physiological saline Kidney Lung Public Health Environmental and Occupational Health Brain Oxides Rat brain Pollution Rats Endocrinology medicine.anatomical_structure Manganese Compounds chemistry Organ Specificity Female Analysis of variance |
| Zdroj: | Reviews on Environmental Health. 14 |
| ISSN: | 2191-0308 0048-7554 |
| DOI: | 10.1515/reveh.1999.14.4.251 |
| Popis: | Manganese retention was observed in brains and in several other tissues of female Wistar rats after the intratracheal instillation of an inorganic manganese compound: manganese dioxide. Two categories of rats, younger (180 to 200g) and older (330 to 350g), were divided into a control group, in which animals received vehicle only (0.5 mL physiological saline), and an experimental group, in which rats received a dose of 0.48 mg of Mn/kg body weight (in 0.5 mL saline), twice a week for 3 months, for a total dosage of 11.80 mg of Mn/kg body weight. At the end of the exposure period, manganese retention in selected rat organs, brain, liver, kidney, and lung, was analyzed using atomic absorption spectrophotometry. At the end of the 6-wk or 12-wk manganese dioxide exposure period, analysis of variance of the manganese retention results revealed significant differences between Mn-exposed and unexposed rats in brain, kidney, and lung tissues (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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