Dose–Response Relationship and Threshold Drug Dosage Identification for a Novel Hybrid Mechanical-Thrombolytic System with an Ultra-Low Dose Patch
| Autor: | Peter Y.M. Woo, Zhen Qin, David Chuen Chun Lam, Chi Hang Chon, John Ching Kwong Kwok |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Intracerebral hemorrhage
Drug medicine.medical_specialty Ultra low dose business.industry medicine.medical_treatment media_common.quotation_subject Thrombolysis medicine.disease General Biochemistry Genetics and Molecular Biology Dose–response relationship medicine.anatomical_structure Modeling and Simulation Internal medicine medicine Cardiology Thrombolytic Agent Original Article Endovascular treatment business Blood vessel media_common |
| Zdroj: | Cell Mol Bioeng |
| ISSN: | 1865-5033 1865-5025 |
| Popis: | INTRODUCTION: Ischemic stroke treatment has advanced in the last two decades and intravenous thrombolysis is now considered the standard of care for selected patients. Recanalization can also be achieved by mechanical endovascular treatment for patients with large vessel occlusions. Complicating treatment-related symptomatic intracerebral hemorrhage and prolonged needle-to-recanalization times have been identified as major determinants of poor three-month functional outcomes. A hybrid mechanical-thrombolytic system with a patch imbued with an ultra-low dose of thrombolytic agents loaded onto a stent-retriever has been developed. METHODS: In this study, the in situ dose–response relationship of the thrombolytic patch imbued with up to 1000 IU of urokinase plasminogen activator (uPA) was quantified using Raman spectroscopy. RESULTS: Thrombi of up to 400 μm thickness dissolved within 15 min when patches imbued with |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink