Cognitive behavioral markers of neurodevelopmental trajectories in rodents
| Autor: | Patrick M. Sexton, Warda Syeda, Liliana Laskaris, Arthur Christopoulos, Cassandra Wannan, Jiaqi K Luo, Antonia Merritt, Christos Pantelis, K H Christopher Choy, Jess Nithianantharajah |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Rodentia Neurosciences. Biological psychiatry. Neuropsychiatry Article Learning and memory 03 medical and health sciences Cellular and Molecular Neuroscience Mice 0302 clinical medicine Cognition Neuroplasticity Moro reflex Biological neural network Cognitive development medicine Psychology Animals Biological Psychiatry Prepulse inhibition 030304 developmental biology 0303 health sciences Working memory Prepulse Inhibition Brain medicine.disease Psychiatry and Mental health Schizophrenia Neurodevelopmental Disorders Female Neuroscience 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021) Translational Psychiatry |
| ISSN: | 2158-3188 |
| Popis: | Between adolescence and adulthood, the brain critically undergoes maturation and refinement of synaptic and neural circuits that shape cognitive processing. Adolescence also represents a vulnerable period for the onset of symptoms in neurodevelopmental psychiatric disorders. Despite the wide use of rodent models to unravel neurobiological mechanisms underlying neurodevelopmental disorders, there is a surprising paucity of rigorous studies focusing on normal cognitive-developmental trajectories in such models. Here, we sought to behaviorally capture maturational changes in cognitive trajectories during adolescence and into adulthood in male and female mice using distinct behavioral paradigms. C57 BL/6J mice (4.5, 6, and 12 weeks of age) were assessed on three behavioral paradigms: drug-induced locomotor hyperactivity, prepulse inhibition, and a novel validated version of a visuospatial paired-associate learning touchscreen task. We show that the normal maturational trajectories of behavioral performance on these paradigms are dissociable. Responses in drug-induced locomotor hyperactivity and prepulse inhibition both displayed a ‘U-shaped’ developmental trajectory; lower during mid-adolescence relative to early adolescence and adulthood. In contrast, visuospatial learning and memory, memory retention, and response times indicative of motivational processing progressively improved with age. Our study offers a framework to investigate how insults at different developmental stages might perturb normal trajectories in cognitive development. We provide a brain maturational approach to understand resilience factors of brain plasticity in the face of adversity and to examine pharmacological and non-pharmacological interventions directed at ameliorating or rescuing perturbed trajectories in neurodevelopmental and neuropsychiatric disorders. |
| Databáze: | OpenAIRE |
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