Childhood T-cell acute lymphoblastic leukaemia expressing 'Ia-like' antigen: A case report

Autor: Ann Kupa, I. Toogood, Kevin Cheney, M E Thomas, Heddy Zola, Ian Beckman, H.A. Moore, J Bradley, Michael J. Rice
Rok vydání: 1982
Předmět:
Zdroj: Medical and Pediatric Oncology. 10:359-367
ISSN: 1096-911X
0098-1532
DOI: 10.1002/mpo.2950100406
Popis: A 4-year-old girl presenting with vomiting, abdominal pain, and renal failure was found to have gross hepatosplenomegaly, a renal mass, and bilateral pleural effusions. A diagnosis of acute lymphoblastic leukaemia (ALL) was suggested by a peripheral white cell count (WCC) of 119,000 × 106/mm3, 57% blasts, 22% lymphocytes, and confirmed by bone marrow examination. Lymphocyte surface marker studies at diagnosis enabled classification as a T-ALL, with a significant proportion of the T cells also bearing receptors for the third component of complement (C3). Seventy-two percent of the peripheral blood mononuclear cells reacted with anti-Ia monoclonal antibody (FMC 4), and a smaller proportion (25%) carried receptors for the Fc portion of IgG. The T-classification of this ALL was verified at central nervous system (CNS) relapse and at a subsequent nodal relapse. Double-marker studies on cells from the infiltrated lymph node prepared in suspension confirmed the presence of Ia-positive T cells. The Ia marker is usually a useful discriminant between T and non-T cells in normal and ALL cell populations. The case described here highlights the need for a panel of markers to be used in classification of childhood ALL and supports the suggestion that there is a distinct subtype of Ia-positive T-ALL.
Databáze: OpenAIRE
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