Role of adenosine in immunomodulation: Review of the literature
| Autor: | Kevin McCallion, K R Gardiner, Denis W. Harkin |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Adenosine Critical Care Critical Illness Multiple Organ Failure Ischemia Stimulation Critical Care and Intensive Care Medicine Risk Assessment Neutrophil Activation Sepsis Intensive care medicine Animals Humans Randomized Controlled Trials as Topic business.industry Organ dysfunction Immunity medicine.disease Survival Analysis Disease Models Animal Treatment Outcome Reperfusion Injury Immunology Female medicine.symptom Multiple organ dysfunction syndrome business Reperfusion injury Follow-Up Studies medicine.drug |
| Zdroj: | Critical Care Medicine. 32:273-277 |
| ISSN: | 0090-3493 |
| DOI: | 10.1097/01.ccm.0000098026.12020.45 |
| Popis: | Advances in the understanding of sepsis have failed to deliver satisfactory new treatments aimed at attenuating inflammatory-mediated organ dysfunction. Phagocytic cells play a pivotal role in driving the inflammatory response and causing direct tissue injury. Adenoreceptor stimulation may attenuate such inflammatory-mediated damage by down-regulating phagocytic activity and preventing excessive respiratory burst activation.A Medline database was used to perform a literature search for all articles relating to the use of adenosine as an immunomodulatory agent.There is convincing evidence to suggest that adenoreceptor modulation can prevent tissue injury through a variety of pathways. The use of adenosine modulation in ischemia/reperfusion injury has been the subject of considerable investigation, although experience with its use in sepsis is limited. |
| Databáze: | OpenAIRE |
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