Receptors for leptin in the otic labyrinth and the cochlear-vestibular nerve of guinea pig are modified in hormone-induced anorexia

Autor: Kathleen C. Horner, Marie-Pierre Blanchard, Juliette Pio, Jean-Denis Troadec, Michel Dallaporta
Přispěvatelé: Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2010
Předmět:
Male
MESH: Drug Implants
Bone remodeling
Immunolabeling
0302 clinical medicine
MESH: Animals
Drug Implants
0303 health sciences
Estradiol
Leptin
Vestibulocochlear Nerve
Immunohistochemistry
Sensory Systems
Anorexia
medicine.anatomical_structure
Receptors
Leptin
MESH: Neuroglia
Female
MESH: Estradiol
Neuroglia
medicine.medical_specialty
Guinea Pigs
MESH: Receptors
Leptin
Vestibulocochlear nerve
MESH: Guinea Pigs
03 medical and health sciences
MESH: Vestibulocochlear Nerve
Internal medicine
medicine
otorhinolaryngologic diseases
Animals
Inner ear
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
030304 developmental biology
Leptin receptor
business.industry
Cochlear nerve
MESH: Immunohistochemistry
Vestibular nerve
MESH: Male
MESH: Astrocytes
Disease Models
Animal
Endocrinology
Astrocytes
Ear
Inner
MESH: Anorexia
sense organs
MESH: Disease Models
Animal
business
MESH: Female
030217 neurology & neurosurgery
MESH: Ear
Inner
Zdroj: Hearing Research
Hearing Research, Elsevier, 2010, 270 (1-2), pp.48-55. ⟨10.1016/j.heares.2010.09.009⟩
Hearing Research, 2010, 270 (1-2), pp.48-55. ⟨10.1016/j.heares.2010.09.009⟩
ISSN: 1878-5891
0378-5955
DOI: 10.1016/j.heares.2010.09.009⟩
Popis: International audience; Metabolic syndromic inner ear pathology is a recognized condition in clinical practice but the possible causes remain controversial. We have previously reported that chronically-implanted estrogen implants in guinea pig results in hyperprolactinemia and hearing loss together with otic bone dysmorphology. The animals also present with anorexia. The hormone leptin has major roles in the regulation of satiety as well as bone metabolism and so we hypothesized that leptin might contribute to pathology of the otic labyrinth. We employed immunohistochemistry to investigate leptin receptor (ObR) expression. In control animals, ObR immunolabeling was not detected in the bone of the otic capsule but immunolabeling was observed in the cochlear-vestibular nerve. The labeling was associated with the astrocytic glial dome area, which marks the transition between central and peripheral parts of the nerve. In estrogen-treated animals, positive-ObR immunolabeling was observed in osteoblasts in new bone of the otic capsule and the ObR labeling was reduced in the cochlear-vestibular nerve compared to controls. The data provide evidence that leptin may target the labyrinth - affecting the bone and the nerve - and so could contribute to ongoing protection of the inner ear. Leptin disturbance might contribute to metabolic syndromes involving the audiovestibular system.
Databáze: OpenAIRE
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